Phenotypes associated with this allele

• Allele Symbol: Qki^qk-shk
• Allele Name: quaking shaking
• Allele ID: MGI:5637515
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Qki^qk-shk/Qki^qk-shk	involves: 129 * C57BL/6	MGI:5637521
ht2	Qki^qk-2J/Qki^qk-shk	involves: 129 * C57BL/6 * C57BLKS/J	MGI:5637522

Genotype
MGI:5637521

hm1

• Allelic Composition: Qki^qk-shk/Qki^qk-shk
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:220956 )

N • mice do not exhibit paresis and normal strength

tremors ( J:220956 )

• at P12

impaired coordination ( J:220956 )

• mice grip walking surface rather than walk

short stride length ( J:220956 )

tonic seizures ( J:220956 )

• after 6 weeks and lasting throughout adulthood, typically motion induced

nervous system

tonic seizures ( J:220956 )

• after 6 weeks and lasting throughout adulthood, typically motion induced

decreased myelin sheath thickness ( J:220956 )

• in the cervical spinal cord at 3 weeks to 2 years of age

abnormal paranode morphology ( J:220956 )

• scalloping of the axolemma with reduced number of transverse bands

demyelination ( J:220956 )

• decreased number of myelinated axons in the cervical spinal cord at 3 weeks to 2 years of age

Genotype
MGI:5637522

ht2

• Allelic Composition: Qki^qk-2J/Qki^qk-shk
• Genetic Background: involves: 129 * C57BL/6 * C57BLKS/J

behavior/neurological

tremors ( J:220956 )