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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Orai1tm1.1Hjm
targeted mutation 1.1, Helen J McBride
MGI:5637538
Summary 2 genotypes


Genotype
MGI:5908389
cn1
Allelic
Composition		 Orai1tm1.1Hjm/Orai1tm1.1Hjm
Orai2tm1.1(KOMP)Vlcg/Orai2tm1.1(KOMP)Vlcg
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 B6.Cg-Tg(Cd4-cre)1Cwi Orai1tm1.1Hjm Orai2tm1.1(KOMP)Vlcg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Orai1tm1.1Hjm mutation (0 available); any Orai1 mutation (22 available)
Orai2tm1.1(KOMP)Vlcg mutation (0 available); any Orai2 mutation (14 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:241365 )
N
• frequencies of T cells
spleen hyperplasia ( J:241365 )
• elevated numbers of immune cell populations at age >3 months
• elevated numbers of CD4+ and CD8+ T cells with CD44hiCD62Lhi memory and/or CD44hiCD62Llo effector phenotypes
decreased germinal center B cell number ( J:241365 )
• CD19+ CD38- GL.7+ in spleen after lymphocytic choriomeningitis virus (LCMV) infection
decreased regulatory T cell number ( J:241365 )
• decreased Foxp3+ cells in thymus, spleen and lymph nodes
decreased single-positive T cell number ( J:241365 )
• severely compromised proliferation of CD4+ cells
abnormal CD4-positive helper T cell morphology ( J:241365 )
• reduced number in spleen after lymphocytic choriomeningitis virus (LCMV) infection
decreased IgG level ( J:241365 )
• after lymphocytic choriomeningitis virus (LCMV) infection
abnormal T cell physiology ( J:241365 )
• SOCE (store-operated Ca2+ entry) completely abolished in naive CD4+ and CD8+ T cells after induction by depletion of ER Ca2+ stores with thapsigargin

immune system
immune system phenotype ( J:241365 )
N
• IgM level after lymphocytic choriomeningitis virus (LCMV) infection
spleen hyperplasia ( J:241365 )
• elevated numbers of immune cell populations at age >3 months
• elevated numbers of CD4+ and CD8+ T cells with CD44hiCD62Lhi memory and/or CD44hiCD62Llo effector phenotypes
decreased germinal center B cell number ( J:241365 )
• CD19+ CD38- GL.7+ in spleen after lymphocytic choriomeningitis virus (LCMV) infection
decreased regulatory T cell number ( J:241365 )
• decreased Foxp3+ cells in thymus, spleen and lymph nodes
decreased single-positive T cell number ( J:241365 )
• severely compromised proliferation of CD4+ cells
abnormal CD4-positive helper T cell morphology ( J:241365 )
• reduced number in spleen after lymphocytic choriomeningitis virus (LCMV) infection
decreased IgG level ( J:241365 )
• after lymphocytic choriomeningitis virus (LCMV) infection
abnormal T cell physiology ( J:241365 )
• SOCE (store-operated Ca2+ entry) completely abolished in naive CD4+ and CD8+ T cells after induction by depletion of ER Ca2+ stores with thapsigargin
lymph node hyperplasia ( J:241365 )
• elevated numbers of immune cell populations at age >3 months

growth/size/body
spleen hyperplasia ( J:241365 )
• elevated numbers of immune cell populations at age >3 months
• elevated numbers of CD4+ and CD8+ T cells with CD44hiCD62Lhi memory and/or CD44hiCD62Llo effector phenotypes




Genotype
MGI:5908391
cn2
Allelic
Composition		 Orai1tm1.1Hjm/Orai1tm1.1Hjm
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 B6.Cg-Orai1tm1.1Hjm Tg(Cd4-cre)1Cwi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Orai1tm1.1Hjm mutation (0 available); any Orai1 mutation (22 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell physiology ( J:241365 )
• SOCE (store-operated Ca2+ entry) reduced by 3050% in naive CD4+ and CD8+ T cells after induction by depletion of ER Ca2+ stores with thapsigargin

immune system
abnormal T cell physiology ( J:241365 )
• SOCE (store-operated Ca2+ entry) reduced by 3050% in naive CD4+ and CD8+ T cells after induction by depletion of ER Ca2+ stores with thapsigargin




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory