Phenotypes associated with this allele

• Allele Symbol: Trp53inp2^tm1Azo
• Allele Name: targeted mutation 1, Antonio Zorzano
• Allele ID: MGI:5637673
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Trp53inp2^tm1Azo/Trp53inp2^tm1Azo Myl1^tm1(cre)Sjb/Myl1^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:6279199

Genotype
MGI:6279199

cn1

• Allelic Composition: Trp53inp2^tm1Azo/Trp53inp2^tm1Azo; Myl1^tm1(cre)Sjb/Myl1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

impaired autophagy ( J:212763 )

• mice show increased levels of LC3I and LC3II and mice treated with chloroquine to inhibit lysosomal protein degradation show a lower accumulatio of LC3II indicating reduced autophagy flux in muscle

• streptozotocin-treated mice show a blunted reduction in LC3I levels indicating reduced autophagy

growth/size/body

increased lean body mass ( J:212763 )

• increase in lean tissue volume

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:212763 )

N • 4 month old mice show no difference in glycemia and they respond normally in a glucose tolerance test

impaired autophagy ( J:212763 )

• mice show increased levels of LC3I and LC3II and mice treated with chloroquine to inhibit lysosomal protein degradation show a lower accumulatio of LC3II indicating reduced autophagy flux in muscle

• streptozotocin-treated mice show a blunted reduction in LC3I levels indicating reduced autophagy

decreased physiological sensitivity to xenobiotic ( J:212763 )

• streptozotocin-treated mice show less muscle loss and a blunted reduction in LC3I levels indicating reduced autophagy

• however, mice show no differences from wild-type mice in the regeneration of cardiotoxin-induced muscle damage

muscle

abnormal skeletal muscle morphology ( J:212763 )

• mice show less muscle loss upon induction of diabetes with streptozotocin than wild-type mice indicating partial protection of muscle wasting induced by diabetes

increased skeletal muscle fiber diameter ( J:212763 )

• increase in cross-sectional area of muscle fibers, with an increase in area of type IIb, IIx, and IIa myofibers from tibialis anterior muscles

• however, no histological abnormalities or changes in fiber-type composition are seen and mitochondrial content and functionality are normal in myofibers

increased skeletal muscle weight ( J:212763 )

• mice show increased tibialis anterior, gastrocnemius, and quadriceps muscle weights

• however, no changes in body weight or food intake are seen

skeletal muscle hypertrophy ( J:212763 )