Analysis Tools
behavior/neurological
|
• mice show impaired memory in the Y-maze test at 18 months of age
|
homeostasis/metabolism
amyloidosis
(
J:212758
)
|
• mice exhibit cortical amyloidosis after 6 months of age
|
|
• mice produce more amyloid beta42 than controls, which increase with age and progressive amyloid beta pathology
• the ratio of amyloid beta42 to amyloid beta40 is increased
• initial amyloid beta deposition is seen at 6 months of age
• amyloid beta1-42 appears initially, followed by amyloid beta3(pE)-42 and amyloid betaX-40 is a minor species
|
hematopoietic system
microgliosis
(
J:212758
)
|
• accumulation of microglia, a sign of neuroinflammation, around the amyloid beta plaques
|
immune system
microgliosis
(
J:212758
)
|
• accumulation of microglia, a sign of neuroinflammation, around the amyloid beta plaques
|
nervous system
microgliosis
(
J:212758
)
|
• accumulation of microglia, a sign of neuroinflammation, around the amyloid beta plaques
|
|
• mice produce more amyloid beta42 than controls, which increase with age and progressive amyloid beta pathology
• the ratio of amyloid beta42 to amyloid beta40 is increased
• initial amyloid beta deposition is seen at 6 months of age
• amyloid beta1-42 appears initially, followed by amyloid beta3(pE)-42 and amyloid betaX-40 is a minor species
|
astrocytosis
(
J:212758
)
|
• accumulation of activated astrocytes, a sign of neuroinflammation, around the amyloid beta plaques
|
|
• synaptic alternations as indicated by loss of synaptophysin and PSD95 immunoreactivity
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Alzheimer's disease | DOID:10652 | J:212758 | ||
