Phenotypes associated with this allele

• Allele Symbol: Tg(Tcrb-TCF3/PBX1)23Gusa
• Allele Name: transgene insertion 23, Guy Sauvageau
• Allele ID: MGI:5638104
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Cd3e^tm1Mal/Cd3e^tm1Mal Tg(Tcrb-TCF3/PBX1)23Gusa/0	involves: C3H * C57BL/6 * C57BL/6J	MGI:5638106
tg2	Tg(Tcrb-TCF3/PBX1)23Gusa/0	involves: C3H * C57BL/6 * C57BL/6J	MGI:5638105

Genotype
MGI:5638106

cx1

• Allelic Composition: Cd3e^tm1Mal/Cd3e^tm1Mal; Tg(Tcrb-TCF3/PBX1)23Gusa/0
• Genetic Background: involves: C3H * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased leukemia incidence ( J:95693 )

• leukemia tumor development penetrance is 87%

• mice intraperitonally injected with MMLV show accelerated pre-B-cell leukemia formation compared to controls

increased acute lymphoblastic leukemia incidence ( J:95693 )

• 40% of mice develop B-cell acute lymphoblastic leukemia

• however, mice do not develop T-cell acute lymphoblastic leukemia, myeloid leukemia, or mixed B-cell/myeloid leukemia

• B-cell leukemia development is accelerated compared to single Tg(Tcrb-TCF3/PBX1)23Gusa transgenic mice

• B-cell tumors are B220+/CD43-/CD19+/IgM-/Pax5+, indicating a pre-B-cell phenotype, and contain IgH chain rearrangements, mostly of the kappa light chain

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acute leukemia		DOID:12603	OMIM:308960	J:95693

Genotype
MGI:5638105

tg2

• Allelic Composition: Tg(Tcrb-TCF3/PBX1)23Gusa/0
• Genetic Background: involves: C3H * C57BL/6 * C57BL/6J

endocrine/exocrine glands

decreased thymocyte number ( J:95693 )

• young mice show a 2- to 4-fold decrease in the number of thymocytes

neoplasm

increased leukemia incidence ( J:95693 )

• mice begin to develop leukemia at 3-4 months of age

• tumor development penetrance is 88%

• 4% of mice develop mixed B-cell/myeloid leukemia

• 4% of mice develop myeloid leukemia

• mice that die before 400 days of age almost all develop T-cell leukemia, while those that die at an older age develop either B-cell leukemia, myeloid leukemia, a mixed B-cell/myeloid leukemia or T-cell/myeloid leukemia

• mice show a lag period of almost 100 days between the last mouse to succumb to T-cell leukemia and the onset of B-cell or B-cell/myeloid leukemia

increased acute lymphoblastic leukemia incidence ( J:95693 )

• 13% of mice develop B-cell acute lymphoblastic leukemia

• 33% of mice develop T-cell acute lymphoblastic leukemia

• B-cell leukemia expresses B220 and lacks expression of surface IgM, suggesting pre-B-cell origin, and shows kappa light chain rearrangement

hematopoietic system

decreased thymocyte number ( J:95693 )

• young mice show a 2- to 4-fold decrease in the number of thymocytes

immune system

decreased thymocyte number ( J:95693 )

• young mice show a 2- to 4-fold decrease in the number of thymocytes