Analysis Tools
endocrine/exocrine glands
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• young mice show a 2- to 4-fold decrease in the number of thymocytes
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neoplasm
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• mice begin to develop leukemia at 3-4 months of age
• tumor development penetrance is 97%
• 8% of mice develop myeloid leukemia
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• 4% of mice develop B-cell acute lymphoblastic leukemia
• 50% of mice develop T-cell acute lymphoblastic leukemia
• mice that develop T-cell leukemia die within 400 days; most die before the occurrence of B-cell tumors
• B and T leukemic cells infiltrate into bone marrow, spleen, thymus, lymph nodes, and frequently nonhematopoietic organs such as liver and lung
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hematopoietic system
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• young mice show a 2- to 4-fold decrease in the number of thymocytes
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immune system
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• young mice show a 2- to 4-fold decrease in the number of thymocytes
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