About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Vdac2tm1.1Ehyc
targeted mutation 1.1, Emily HY Cheng
MGI:5638533
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Vdac2tm1.1Ehyc/Vdac2tm1.1Ehyc
Bak1tm1Thsn/Bak1tm1Thsn
Tg(Lck-cre)1Cwi/? 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 MGI:5691371
cn2
 		Vdac2tm1.1Ehyc/Vdac2tm1.1Ehyc
Tg(Lck-cre)1Cwi/? 		involves: 129X1/SvJ * C57BL/6 * DBA/2 MGI:5691369
cn3
 		Vdac2tm1.1Ehyc/Vdac2tm1.1Ehyc
Baxtm2Sjk/Baxtm2Sjk
Tg(Lck-cre)1Cwi/? 		involves: 129X1/SvJ * C57BL/6 * DBA/2 MGI:5691375


Genotype
MGI:5691371
cn1
Allelic
Composition		 Vdac2tm1.1Ehyc/Vdac2tm1.1Ehyc
Bak1tm1Thsn/Bak1tm1Thsn
Tg(Lck-cre)1Cwi/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1tm1Thsn mutation (2 available); any Bak1 mutation (25 available)
Tg(Lck-cre)1Cwi mutation (3 available)
Vdac2tm1.1Ehyc mutation (0 available); any Vdac2 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:220951 )
N
• thymus size normal
• thymocyte number normal
• no increase in apoptosis




Genotype
MGI:5691369
cn2
Allelic
Composition		 Vdac2tm1.1Ehyc/Vdac2tm1.1Ehyc
Tg(Lck-cre)1Cwi/?
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Lck-cre)1Cwi mutation (3 available)
Vdac2tm1.1Ehyc mutation (0 available); any Vdac2 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal thymocyte apoptosis ( J:220951 )
• BAK from T cells is more sensitive to apoptotic signals
• earlier translocation of cytochrome c out of mitochondria
• earlier caspase activation
• thymocytes cultured with antibody to CD3 die more rapidly
small thymus ( J:220951 )
• further shrinkage of thymus when mice injected with antibody to CD3
decreased thymocyte number ( J:220951 )
• two fold reduction of thymocytes although the developmental profile seems normal
• 90% of double+ thymocytes killed when mice injected with antibody to CD3

cellular
abnormal thymocyte apoptosis ( J:220951 )
• BAK from T cells is more sensitive to apoptotic signals
• earlier translocation of cytochrome c out of mitochondria
• earlier caspase activation
• thymocytes cultured with antibody to CD3 die more rapidly

hematopoietic system
abnormal thymocyte apoptosis ( J:220951 )
• BAK from T cells is more sensitive to apoptotic signals
• earlier translocation of cytochrome c out of mitochondria
• earlier caspase activation
• thymocytes cultured with antibody to CD3 die more rapidly
small thymus ( J:220951 )
• further shrinkage of thymus when mice injected with antibody to CD3
decreased thymocyte number ( J:220951 )
• two fold reduction of thymocytes although the developmental profile seems normal
• 90% of double+ thymocytes killed when mice injected with antibody to CD3

endocrine/exocrine glands
abnormal thymocyte apoptosis ( J:220951 )
• BAK from T cells is more sensitive to apoptotic signals
• earlier translocation of cytochrome c out of mitochondria
• earlier caspase activation
• thymocytes cultured with antibody to CD3 die more rapidly
small thymus ( J:220951 )
• further shrinkage of thymus when mice injected with antibody to CD3
decreased thymocyte number ( J:220951 )
• two fold reduction of thymocytes although the developmental profile seems normal
• 90% of double+ thymocytes killed when mice injected with antibody to CD3




Genotype
MGI:5691375
cn3
Allelic
Composition		 Vdac2tm1.1Ehyc/Vdac2tm1.1Ehyc
Baxtm2Sjk/Baxtm2Sjk
Tg(Lck-cre)1Cwi/?
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Baxtm2Sjk mutation (1 available); any Bax mutation (24 available)
Tg(Lck-cre)1Cwi mutation (3 available)
Vdac2tm1.1Ehyc mutation (0 available); any Vdac2 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte number ( J:220951 )
• two fold reduction of thymocytes although the developmental profile seems normal

hematopoietic system
decreased thymocyte number ( J:220951 )
• two fold reduction of thymocytes although the developmental profile seems normal

endocrine/exocrine glands
decreased thymocyte number ( J:220951 )
• two fold reduction of thymocytes although the developmental profile seems normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory