Phenotypes associated with this allele

• Allele Symbol: Camk2b^tm1.1Ics
• Allele Name: targeted mutation 1.1, Mouse Clinical Institute
• Allele ID: MGI:5638541
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Camk2b^tm1.1Ics/Camk2b^tm1.1Ics	B6J.129S2(Cg)-Camk2b^tm1.1Ics	MGI:5688767
ht2	Camk2b^tm1.1Ics/Camk2b^+	B6J.129S2(Cg)-Camk2b^tm1.1Ics	MGI:5688768

Genotype
MGI:5688767

hm1

• Allelic Composition: Camk2b^tm1.1Ics/Camk2b^tm1.1Ics
• Genetic Background: B6J.129S2(Cg)-Camk2b^tm1.1Ics

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:219040 )

N • homozygotes show no differences in water or food intake relative to wild-type controls

abnormal object recognition memory ( J:219040 )

• in a novel object recognition task, adult homozygotes show no preference for the novel object 4 hours after the training session, unlike wild-type controls

decreased anxiety-related response ( J:219040 )

• in the elevated plus maze task, adult homozygotes spend significantly more time in the open arms and less time in the closed arms relative to wild-type controls

• however, no deficit in depth perception is observed in a visual cliff test, indicating normal ability to visually determine the difference between open and closed arms of the maze

impaired balance ( J:219040 )

• in a balance task involving three beams of increasing difficulty, adult homozygotes show significantly more foot slips on all beam widths relative to wild-type or heterozygous controls

impaired coordination ( J:219040 )

• adult homozygotes fall after ~30 seconds on the rotarod, unlike wild-type or heterozygous controls which fall after 1.5 to 2 minutes, respectively

decreased grip strength ( J:219040 )

• at 3-4 months of age, adult homozygotes show impaired forelimb grip strength but not hindlimb grip strength

abnormal voluntary movement ( J:219040 )

• in a voluntary running wheel, adult homozygotes run significantly less total time and at a significantly slower velocity than wild-type controls

• however, no difference in spontaneous movement is observed in the open field task

ataxia ( J:219040 )

• homozygotes display forelimb ataxia

abnormal nest building behavior ( J:219040 )

• homozygotes make a significantly lower quality nest relative to wild-type or heterozygous controls, leaving the nestlet largely untouched

growth/size/body

decreased body size ( J:219040 )

• at weaning (3-4 weeks of age), homozygotes are smaller than wild-type controls

slow postnatal weight gain ( J:219040 )

• homozygotes have normal birth weight but show significantly lower body weight from approximately 4 to 9 weeks of age

• however, differences in body weight are no longer significant by week 10

adipose tissue

increased percent body fat/body weight ( J:219040 )

• at 12 weeks of age, homozygotes exhibit an increased percentage of fat mass relative to wild-type controls

• no significant differences are noted in total weight and lean mass

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:219040 )

N • homozygotes display no differences in the respiratory exchange ratio relative to wild-type controls

Genotype
MGI:5688768

ht2

• Allelic Composition: Camk2b^tm1.1Ics/Camk2b⁺
• Genetic Background: B6J.129S2(Cg)-Camk2b^tm1.1Ics

behavior/neurological

behavior/neurological phenotype ( J:219040 )

N • heterozygotes show no differences in water or food intake relative to wild-type controls

N • no motor function deficits are observed in the grip strength, rotarod, balance beam, open field, and voluntary running wheel tasks

N • nest building behavior is normal

decreased anxiety-related response ( J:219040 )

• in the elevated plus maze task, heterozygotes spend significantly less time in the closed arms of the maze relative to wild-type controls

adipose tissue

increased percent body fat/body weight ( J:219040 )

• at 12 weeks of age, heterozygotes exhibit an increased percentage of fat mass relative to wild-type controls

• no significant differences are noted in total weight and lean mass

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:219040 )

N • heterozygotes display no differences in the respiratory exchange ratio relative to wild-type controls