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Allele Symbol Allele Name Allele ID |
Rragatm2Dmsa targeted mutation 2, David Sabatini MGI:5638548 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mild reduction in ad libitum blood glucose levels in young mice
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• increased reduction in glycaemia following injection of insulin in an insulin tolerance test
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• over 50% of mice die within 2-3 weeks after the start of tamoxifen treatment
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• frequent apoptotic figures in small intestine after tamoxifen treatment
• small intestinal atrophy
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• transiently lose about 20% of body weight within 1 week of tamoxifen injection
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• expansion of myeloid cells spreads to peripheral tissues in mice that survive more than 2 weeks after tamoxifen treatment
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• expansion of monocytes is accompanied by profound reduction in B lymphocytes and/or their progenitors
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• accumulation of monocytes in the spleen and bone marrow
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• expansion of myeloid cells is histopathologically reminiscent of histiocytic sarcoma
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• frequent apoptotic figures in small intestine after tamoxifen treatment
• small intestinal atrophy
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• frequent apoptotic figures in small intestine after tamoxifen treatment
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• expansion of myeloid cells spreads to peripheral tissues in mice that survive more than 2 weeks after tamoxifen treatment
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• expansion of monocytes is accompanied by profound reduction in B lymphocytes and/or their progenitors
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• accumulation of monocytes in the spleen and bone marrow
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/03/2024 MGI 6.24 |
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