Phenotypes associated with this allele

• Allele Symbol: Capza2^{tm1b(KOMP)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5638561
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Capza2^tm1b(KOMP)Wtsi/Capza2^tm1b(KOMP)Wtsi	C57BL/6N-Capza2^tm1b(KOMP)Wtsi/Wtsi	MGI:5767585
ht2	Capza2^tm1b(KOMP)Wtsi/Capza2^+	C57BL/6N-Capza2^tm1b(KOMP)Wtsi/Wtsi	MGI:6394260

Genotype
MGI:5767585

hm1

• Allelic Composition: Capza2^{tm1b(KOMP)Wtsi}/Capza2^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Capza2^{tm1b(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0705_5_A08

Data Sources

IMPC Data for Capza2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal vertebral artery topology ( J:239583 )

DMDD

dilated liver sinusoidal space ( J:239583 )

DMDD

abnormal ductus venosus valve morphology ( J:239583 )

DMDD

abnormal hepatic vein connection ( J:239583 )

DMDD

muscular ventricular septal defect ( J:239583 )

DMDD

bicuspid aortic valve ( J:239583 )

DMDD

abnormal pulmonary valve cusp morphology ( J:239583 )

DMDD

endocrine/exocrine glands

biliary cyst ( J:239583 )

DMDD

multiple persisting craniopharyngeal ducts ( J:239583 )

DMDD

growth/size/body

biliary cyst ( J:239583 )

DMDD

immune system

blood in lymph vessels ( J:239583 )

DMDD

liver/biliary system

dilated liver sinusoidal space ( J:239583 )

DMDD

biliary cyst ( J:239583 )

DMDD

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - WTSI

neoplasm

increased trigeminal neuroma incidence ( J:239583 )

DMDD

nervous system

multiple persisting craniopharyngeal ducts ( J:239583 )

DMDD

increased trigeminal neuroma incidence ( J:239583 )

DMDD

abnormal hypoglossal nerve topology ( J:239583 )

DMDD

absent hypoglossal nerve ( J:239583 )

DMDD

thin hypoglossal nerve ( J:239583 )

DMDD

normal phenotype

no abnormal phenotype detected ( J:239583 )

DMDD

skeleton

fusion of vertebral arches ( J:239583 )

DMDD

Genotype
MGI:6394260

ht2

• Allelic Composition: Capza2^{tm1b(KOMP)Wtsi}/Capza2⁺
• Genetic Background: C57BL/6N-Capza2^{tm1b(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0705_5_A08

Data Sources

IMPC Data for Capza2

hematopoietic system

increased mean platelet volume ( J:211773 )

IMPC - WTSI

homeostasis/metabolism

increased circulating creatinine level ( J:211773 )

♂

IMPC - WTSI