Phenotypes associated with this allele

• Allele Symbol: Fhip1a^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5638570
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fhip1a^tm1b(EUCOMM)Wtsi/Fhip1a^tm1b(EUCOMM)Wtsi	C57BL/6N-Fhip1a1^tm1b(EUCOMM)Wtsi/Wtsi	MGI:6262405
ht2	Fhip1a^tm1b(EUCOMM)Wtsi/Fhip1a^+	C57BL/6N-Fhip1a1^tm1b(EUCOMM)Wtsi/Wtsi	MGI:5797524

Genotype
MGI:6262405

hm1

• Allelic Composition: Fhip1a^{tm1b(EUCOMM)Wtsi}/Fhip1a^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Fhip1a1^{tm1b(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0698_5_D08

Data Sources

IMPC Data for Fhip1a

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal placenta morphology ( J:261316 )

• branching morphology defect at E9.5

abnormal trophoblast layer morphology ( J:261316 )

• small or absent trophoblast compartment at E9.5

• biased differentiation (diploid/polyploid trophoblast)

abnormal trophoblast giant cell morphology ( J:261316 )

• abnormal trophoblast giant cell size and morphology at E9.5

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

lethality throughout fetal growth and development, complete penetrance ( J:261316 )

• fewer than the expected number of fetuses are seen at E14.5, indicating sub-viability at this time

Genotype
MGI:5797524

ht2

• Allelic Composition: Fhip1a^{tm1b(EUCOMM)Wtsi}/Fhip1a⁺
• Genetic Background: C57BL/6N-Fhip1a1^{tm1b(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0698_5_D08

Data Sources

IMPC Data for Fhip1a

hematopoietic system

decreased erythrocyte cell number ( J:211773 )

♂

IMPC - WTSI

increased mean corpuscular hemoglobin ( J:211773 )

IMPC - WTSI