normal phenotype
• homozygotes are viable and fertile and show no overt phenotypic abnormalities
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Allele Symbol Allele Name Allele ID |
Mau2tm1.1Hpt targeted mutation 1.1, Heiko Peters MGI:5638624 |
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Summary |
4 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• homozygotes are viable and fertile and show no overt phenotypic abnormalities
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• newborn mice display open eyelids
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• at E10.5, the number of proliferating cells in the first branchial arch mesenchyme is reduced by ~25%
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• newborn mice exhibit severe facial hypoplasia
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• a mild size reduction of the upper lip is first seen at E13.5
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• an up-turned nose is first seen at E13.5
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• newborn mice have low-set ears
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• proliferation of neural crest cells is reduced as early as E10.5; however, these cells continue to expand and are capable of differentiating into cartilage and bone, esp. in the distal region of the maxilla and mandible, respectively
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• at E10.5, the number of proliferating cells in the first branchial arch mesenchyme is reduced by ~25%
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• all neural crest cell-derived skull components are severely affected
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• all neural crest cell-derived jaw components are severely affected
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• a mild size reduction of the lower jaw is first seen at E13.5
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• in newborn mice, the length of the mandible is only 49% of that in wild-type controls, i.e. significantly smaller than that of mice that are double homozygous for both Nipbltm1.1Hpt and Mau2tm1.1Hpt and hemizygous for Tg(Wnt1-cre)11Rth (68% of wild-type controls)
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• surprisingly, newborn mice exhibit a more pronounced craniofacial phenotype relative to not only mice that are singly homozygous for Nipbltm1.1Hpt and hemizygous for Tg(Wnt1-cre)11Rth, but also to mice that are double homozygous for both Nipbltm1.1Hpt and Mau2tm1.1Hpt and hemizygous for Tg(Wnt1-cre)11Rth
|
• at E10.5, the number of proliferating cells in the first branchial arch mesenchyme is reduced by ~25%
|
• newborn mice exhibit severe facial hypoplasia
|
• a mild size reduction of the upper lip is first seen at E13.5
|
• an up-turned nose is first seen at E13.5
|
• newborn mice have low-set ears
|
• all neural crest cell-derived skull components are severely affected
|
• all neural crest cell-derived jaw components are severely affected
|
• a mild size reduction of the lower jaw is first seen at E13.5
|
• in newborn mice, the length of the mandible is only 49% of that in wild-type controls, i.e. significantly smaller than that of mice that are double homozygous for both Nipbltm1.1Hpt and Mau2tm1.1Hpt and hemizygous for Tg(Wnt1-cre)11Rth (68% of wild-type controls)
|
• proliferation of neural crest cells is reduced as early as E10.5; however, these cells continue to expand and are capable of differentiating into cartilage and bone, esp. in the distal region of the maxilla and mandible, respectively
|
• newborn mice have low-set ears
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• newborn mice display open eyelids
|
• newborn mice exhibit severe facial hypoplasia
|
• newborn mice have low-set ears
|
• all neural crest cell-derived skull components are severely affected
|
• all neural crest cell-derived jaw components are severely affected
|
• in newborn mice, the length of the mandible is 68% of that in wild-type controls i.e. significantly larger than that of mice that are singly homozygous for Mau2tm1.1Hpt and hemizygous for Tg(Wnt1-cre)11Rth (49% of wild-type controls)
|
• surprisingly, newborn mice exhibit a less pronounced craniofacial phenotype relative to mice that are singly homozygous for Mau2tm1.1Hpt and hemizygous for Tg(Wnt1-cre)11Rth
|
• newborn mice exhibit severe facial hypoplasia
|
• newborn mice have low-set ears
|
• all neural crest cell-derived skull components are severely affected
|
• all neural crest cell-derived jaw components are severely affected
|
• in newborn mice, the length of the mandible is 68% of that in wild-type controls i.e. significantly larger than that of mice that are singly homozygous for Mau2tm1.1Hpt and hemizygous for Tg(Wnt1-cre)11Rth (49% of wild-type controls)
|
• newborn mice have low-set ears
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• in newborn mice, the length of the mandible is 62% of that in wild-type controls, i.e. intermediate between that of mice that are singly homozygous for Mau2tm1.1Hpt and hemizygous for Tg(Wnt1-cre)11Rth (49% of wild-type controls) and mice that are double homozygous for both Nipbltm1.1Hpt and Mau2tm1.1Hpt and hemizygous for Tg(Wnt1-cre)11Rth (68% of wild-type controls)
|
• in newborn mice, the length of the mandible is 62% of that in wild-type controls, i.e. intermediate between that of mice that are singly homozygous for Mau2tm1.1Hpt and hemizygous for Tg(Wnt1-cre)11Rth (49% of wild-type controls) and mice that are double homozygous for both Nipbltm1.1Hpt and Mau2tm1.1Hpt and hemizygous for Tg(Wnt1-cre)11Rth (68% of wild-type controls)
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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