Phenotypes associated with this allele

• Allele Symbol: Ppargc1b^tm1.1Javi
• Allele Name: targeted mutation 1.1, Josep A Villena
• Allele ID: MGI:5638648
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ppargc1b^tm1.1Javi/Ppargc1b^tm1.1Javi Tg(Fabp4-cre)1Rev/?	involves: 129P2/OlaHsd * C57BL/6J	MGI:5696655

Genotype
MGI:5696655

cn1

• Allelic Composition: Ppargc1b^tm1.1Javi/Ppargc1b^tm1.1Javi; Tg(Fabp4-cre)1Rev/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

growth/size/body region phenotype ( J:221221 )

N • no gross abnormalities in body weight or size of major organs

N • diet has no affect on body size in mice raised at 30C

adipose tissue

adipose tissue phenotype ( J:221221 )

N • white adipose tissue weight is normal

N • brown adipose tissue more normal in appearance when mice are raised at 30C

increased brown adipose tissue amount ( J:221221 )

• 50% increase in mass of interscapular brown adipose tissue in mice raised at 21C

abnormal brown fat cell morphology ( J:221221 )

• histological appearance more like white adipose tissue in mice raised at 21C

increased brown fat cell lipid droplet size ( J:221221 )

• large amounts of triglycerides accumulated in a single large vacuole in mice raised at 21C

decreased brown fat lipid droplet number ( J:221221 )

• large amounts of triglycerides accumulated in a single large vacuole in mice raised at 21C

behavior/neurological

behavior/neurological phenotype ( J:221221 )

N • food intake similar to controls

cellular

abnormal mitochondrial physiology ( J:221221 )

• roziglitazone up regulation of mitochondrial gene expression fails

abnormal tricarboxylic acid cycle ( J:221221 )

• many TCA cycle genes are down regulated in white adipose tissue

abnormal respiratory electron transport chain ( J:221221 )

• many respiratory chain enzymes are down regulated in white adipose tissue

abnormal oxidative phosphorylation ( J:221221 )

• many oxidative phosphorylation pathway genes are down regulated

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:221221 )

N • glucose tolerance responses are normal

N • insulin sensitivity is comparable to controls

N • glucose and insulin responses to rosiglitazone are normal