Phenotypes associated with this allele

• Allele Symbol: Arhgef28^tm1.1Ddsr
• Allele Name: targeted mutation 1.1, David D Schlaepfer
• Allele ID: MGI:5638671
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arhgef28^tm1.1Ddsr/Arhgef28^tm1.1Ddsr	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac * BALB/cJ	MGI:5693642

Genotype
MGI:5693642

hm1

• Allelic Composition: Arhgef28^tm1.1Ddsr/Arhgef28^tm1.1Ddsr
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac * BALB/cJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Reduced size of Arhgef28^tm1.1Ddsr/Arhgef28^tm1.1Ddsr mice at 4 weeks

growth/size/body

decreased birth body size ( J:221026 )

• produced in fewer than expected numbers as observed at 3 weeks of age

• smaller in size than controls

increased growth rate ( J:221026 )

• catch up to control body size by 6-8 weeks of age

reproductive system

reproductive system phenotype ( J:221026 )

N • fertile

cellular

decreased fibroblast cell migration ( J:221026 )

• cell movement inhibited in immortalized MEFs

• form fewer focal adhesions at 90 and 120 minutes than do controls when plated on fibronectin coated plates

• focal adhesions smaller in size