Phenotypes associated with this allele

• Allele Symbol: Orc6^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:5638892
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Orc6^em1(IMPC)J/Orc6^em1(IMPC)J	C57BL/6NJ-Orc6^em1(IMPC)J/J	MGI:5884021
ht2	Orc6^em1(IMPC)J/Orc6^+	C57BL/6NJ-Orc6^em1(IMPC)J/J	MGI:6263076

Genotype
MGI:5884021

hm1

• Allelic Composition: Orc6^em1(IMPC)J/Orc6^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Orc6^em1(IMPC)J/J

Data Sources

IMPC Data for Orc6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Orc6^em1(IMPC)J/Orc6^em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 but not at E7.5. Embryos at E3.5 appear as dying morulae. Mutants fail to hatch from the zona pellucida with apparent cell death and never reach blastocyst stage in culture.

embryo

failure of blastocyst formation ( J:279207 )

• embryos fail to reach a morphological blastocyst stage after 3 days in culture

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• in culture, embryos fail to hatch from the zona pellucida with apparent cell death after 3 days in culture

embryonic growth arrest ( J:279207 )

• morulas recovered at E3.5 appear to be dying

• embryos show no further development after 3 days in culture

abnormal morula morphology ( J:279207 )

• morulas recovered at E3.5 appear to be dying

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality before implantation, complete penetrance ( J:279207 )

• homozygous embryos are recovered at E3.5 (14% versus expected 25%, n=29) and appear to arrest/die prior to blastocyst formation; no embryos or excess resorption sites are observed at E7.5

Genotype
MGI:6263076

ht2

• Allelic Composition: Orc6^em1(IMPC)J/Orc6⁺
• Genetic Background: C57BL/6NJ-Orc6^em1(IMPC)J/J

Data Sources

IMPC Data for Orc6

behavior/neurological

impaired pupillary reflex ( J:211773 )

♂

IMPC - JAX

hyperactivity ( J:211773 )

IMPC - JAX

homeostasis/metabolism

decreased circulating creatinine level ( J:211773 )

♀

IMPC - JAX

vision/eye

impaired pupillary reflex ( J:211773 )

♂

IMPC - JAX

persistence of hyaloid vascular system ( J:211773 )

♀

IMPC - JAX