Phenotypes associated with this allele

• Allele Symbol: Dock2^m4Btlr
• Allele Name: mutation 4, Bruce Beutler
• Allele ID: MGI:5640757
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dock2^m4Btlr/Dock2^m4Btlr	C57BL/6J-Dock2^m4Btlr	MGI:5641226

Genotype
MGI:5641226

hm1

• Allelic Composition: Dock2^m4Btlr/Dock2^m4Btlr
• Genetic Background: C57BL/6J-Dock2^m4Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal B cell differentiation ( J:221486 )

• increased frequency in some mice in the peripheral blood

abnormal CD4-positive T cell differentiation ( J:221486 )

• some mice show a decrease in the CD4+ to CD8+ T cell ratio caused by a diminished frequency of CD4+ T cells and a reduction in frequency of CD4+ T cells in CD3+ T cells

abnormal CD8-positive, alpha-beta T cell differentiation ( J:221486 )

• increased frequency of CD8+ T cells in CD3+ T cells

immune system

abnormal B cell differentiation ( J:221486 )

• increased frequency in some mice in the peripheral blood

abnormal CD4-positive T cell differentiation ( J:221486 )

• some mice show a decrease in the CD4+ to CD8+ T cell ratio caused by a diminished frequency of CD4+ T cells and a reduction in frequency of CD4+ T cells in CD3+ T cells

abnormal CD8-positive, alpha-beta T cell differentiation ( J:221486 )

• increased frequency of CD8+ T cells in CD3+ T cells