Phenotypes associated with this allele

• Allele Symbol: Ciita^m1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:5640772
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ciita^m1Btlr/Ciita^m1Btlr	C57BL/6J-Ciita^m1Btlr	MGI:5641251

Genotype
MGI:5641251

hm1

• Allelic Composition: Ciita^m1Btlr/Ciita^m1Btlr
• Genetic Background: C57BL/6J-Ciita^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal CD4-positive T cell differentiation ( J:221483 )

• reduced frequencies of CD4+ T cells including naive CD4+ T cells in CD4+ T cells and CD4+ T cells in CD3+ T cells as well as increased CD44+ CD4+ mean fluorescence intensity, all in the peripheral blood

abnormal CD8-positive, alpha-beta T cell differentiation ( J:221483 )

• increased frequencies CD8+ T cells in CD3+ T cells in the peripheral blood

impaired humoral immune response ( J:221483 )

• diminished T-dependent antibody responses to ovalbumin administered with aluminum hydroxide and recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

hematopoietic system

abnormal CD4-positive T cell differentiation ( J:221483 )

• reduced frequencies of CD4+ T cells including naive CD4+ T cells in CD4+ T cells and CD4+ T cells in CD3+ T cells as well as increased CD44+ CD4+ mean fluorescence intensity, all in the peripheral blood

abnormal CD8-positive, alpha-beta T cell differentiation ( J:221483 )

• increased frequencies CD8+ T cells in CD3+ T cells in the peripheral blood