About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rac2m1Btlr
mutation 1, Bruce Beutler
MGI:5640784
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rac2m1Btlr/Rac2m1Btlr C57BL/6J-Rac2m1Btlr MGI:5641246
ht2
 		Rac2m1Btlr/Rac2+ C57BL/6J-Rac2m1Btlr MGI:5641247


Genotype
MGI:5641246
hm1
Allelic
Composition		 Rac2m1Btlr/Rac2m1Btlr
Genetic
Background		 C57BL/6J-Rac2m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rac2m1Btlr mutation (0 available); any Rac2 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgM level ( J:221478 )
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)
impaired humoral immune response ( J:221478 )
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

hematopoietic system
decreased IgM level ( J:221478 )
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)




Genotype
MGI:5641247
ht2
Allelic
Composition		 Rac2m1Btlr/Rac2+
Genetic
Background		 C57BL/6J-Rac2m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rac2m1Btlr mutation (0 available); any Rac2 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgM level ( J:221478 )
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) intermediate between the wild-type and homozygotes
impaired humoral immune response ( J:221478 )
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) intermediate between the wild-type and homozygotes

hematopoietic system
decreased IgM level ( J:221478 )
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) intermediate between the wild-type and homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/22/2024
MGI 6.24 		The Jackson Laboratory