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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rac2m1Btlr
mutation 1, Bruce Beutler
MGI:5640784
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rac2m1Btlr/Rac2m1Btlr C57BL/6J-Rac2m1Btlr MGI:5641246
ht2
 		Rac2m1Btlr/Rac2+ C57BL/6J-Rac2m1Btlr MGI:5641247


Genotype
MGI:5641246
hm1
Allelic
Composition		 Rac2m1Btlr/Rac2m1Btlr
Genetic
Background		 C57BL/6J-Rac2m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rac2m1Btlr mutation (0 available); any Rac2 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgM level ( J:221478 )
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)
impaired humoral immune response ( J:221478 )
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

hematopoietic system
decreased IgM level ( J:221478 )
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)




Genotype
MGI:5641247
ht2
Allelic
Composition		 Rac2m1Btlr/Rac2+
Genetic
Background		 C57BL/6J-Rac2m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rac2m1Btlr mutation (0 available); any Rac2 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgM level ( J:221478 )
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) intermediate between the wild-type and homozygotes
impaired humoral immune response ( J:221478 )
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) intermediate between the wild-type and homozygotes

hematopoietic system
decreased IgM level ( J:221478 )
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) intermediate between the wild-type and homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory