Phenotypes associated with this allele

• Allele Symbol: Myo5a^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:5641704
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myo5a^tm1a(KOMP)Wtsi/Myo5a^tm1a(KOMP)Wtsi	B6Brd;B6N-Tyr^c-Brd Myo5a^tm1a(KOMP)Wtsi/Wtsi	MGI:6273147
hm2	Myo5a^tm1a(KOMP)Wtsi/Myo5a^tm1a(KOMP)Wtsi	B6JTyr;B6N-Myo5a^tm1a(KOMP)Wtsi/Wtsi	MGI:5781679
hm3	Myo5a^tm1a(KOMP)Wtsi/Myo5a^tm1a(KOMP)Wtsi	C57BL/6-Myo5a^tm1a(KOMP)Wtsi	MGI:5641705

Genotype
MGI:6273147

hm1

• Allelic Composition: Myo5a^{tm1a(KOMP)Wtsi}/Myo5a^{tm1a(KOMP)Wtsi}
• Genetic Background: B6Brd;B6N-Tyr^c-Brd Myo5a^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0034_4_C03

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal coat/hair pigmentation ( J:232539 )

diluted coat color ( J:232539 )

pigmentation

abnormal coat/hair pigmentation ( J:232539 )

diluted coat color ( J:232539 )

Genotype
MGI:5781679

hm2

• Allelic Composition: Myo5a^{tm1a(KOMP)Wtsi}/Myo5a^{tm1a(KOMP)Wtsi}
• Genetic Background: B6JTyr;B6N-Myo5a^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0034_4_C03

Data Sources

IMPC Data for Myo5a

behavior/neurological

abnormal behavior ( J:175295 )

IMPC - WTSI

hyperactivity ( J:175295 )

IMPC - WTSI

integument

abnormal coat/hair pigmentation ( J:175295 )

♂

IMPC - WTSI

pigmentation

abnormal coat/hair pigmentation ( J:175295 )

♂

IMPC - WTSI

Genotype
MGI:5641705

hm3

• Allelic Composition: Myo5a^{tm1a(KOMP)Wtsi}/Myo5a^{tm1a(KOMP)Wtsi}
• Genetic Background: C57BL/6-Myo5a^{tm1a(KOMP)Wtsi}
• Cell Lines: EPD0034_4_C03

integument

abnormal coat/hair pigmentation ( J:209956 )

• silver coat color

abnormal hair follicle melanocyte morphology ( J:209956 )

• abnormal melanocyte morphology in the tail interfollicular epidermis

abnormal hair follicle melanin granule morphology ( J:209956 )

• increase in intracellular accumulation of melanin pigment in the tail

abnormal epidermal pigmentation ( J:209956 )

abnormal epidermal melanocyte morphology ( J:209956 )

• abnormal melanocyte morphology in the tail epidermis

• melanosome clumping in epidermal melanocytes

pigmentation

abnormal coat/hair pigmentation ( J:209956 )

• silver coat color

abnormal hair follicle melanocyte morphology ( J:209956 )

• abnormal melanocyte morphology in the tail interfollicular epidermis

abnormal hair follicle melanin granule morphology ( J:209956 )

• increase in intracellular accumulation of melanin pigment in the tail

abnormal epidermal pigmentation ( J:209956 )

abnormal epidermal melanocyte morphology ( J:209956 )

• abnormal melanocyte morphology in the tail epidermis

• melanosome clumping in epidermal melanocytes

abnormal melanosome morphology ( J:209956 )

• melanosome clumping in epidermal melanocytes