Phenotypes associated with this allele

• Allele Symbol: Trp53^tm1Lejo
• Allele Name: targeted mutation 1, Leisa Johnson
• Allele ID: MGI:5641750
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rb1^tm2Brn/Rb1^tm2Brn Trp53^tm1Lejo/Trp53^tm1Lejo	involves: 129	MGI:5441551
cn2	Kras^tm4Tyj/Kras^+ Trp53^tm1Lejo/Trp53^tm1Lejo	involves: 129S4/SvJae	MGI:5441555

Genotype
MGI:5441551

cn1

• Allelic Composition: Rb1^tm2Brn/Rb1^tm2Brn; Trp53^tm1Lejo/Trp53^tm1Lejo
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:187012 )

• adenovirus-FLPe/IRES/Cre (Ad-FIC) induces a dose dependent increase in mortality with no mice surviving to 55 weeks post infection at concentrations greater than or equal to 5.00E+06 infectious units (iu)

• no mice survive to 40 weeks post infection when dosed with 5.00E+07 iu of Ad-FIC

neoplasm

increased lung small cell carcinoma incidence ( J:187012 )

• following infection with Ad-FIC

• early stage tumors are detected by 16 weeks post infection with Ad-FIC and late stage tumors are detected by about 32 weeks post infection

respiratory system

abnormal lung morphology ( J:187012 )

• neuroendocrine hyperplasia is detected at 8 weeks post infection with Ad-FIC

increased lung small cell carcinoma incidence ( J:187012 )

• following infection with Ad-FIC

• early stage tumors are detected by 16 weeks post infection with Ad-FIC and late stage tumors are detected by about 32 weeks post infection

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung small cell carcinoma		DOID:5409	OMIM:182280	J:187012

Genotype
MGI:5441555

cn2

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Trp53^tm1Lejo/Trp53^tm1Lejo
• Genetic Background: involves: 129S4/SvJae

neoplasm

increased lung non-small cell carcinoma incidence ( J:187012 )

• following infection with adenovirus-FLPe/IRES/Cre (Ad-FIC)

increased lung adenocarcinoma incidence ( J:187012 )

• following infection with Ad-FIC

respiratory system

increased lung non-small cell carcinoma incidence ( J:187012 )

• following infection with adenovirus-FLPe/IRES/Cre (Ad-FIC)

increased lung adenocarcinoma incidence ( J:187012 )

• following infection with Ad-FIC

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:187012