Phenotypes associated with this allele

• Allele Symbol: Slc39a10^tm1.1Tfk
• Allele Name: targeted mutation 1.1, Toshiyuki Fukada
• Allele ID: MGI:5642299
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cd79a^tm1(cre)Reth/Cd79a^+ Slc39a10^tm1.1Tfk/Slc39a10^tm1.1Tfk	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J	MGI:6112652
cn2	Slc39a10^tm1.1Tfk/Slc39a10^tm1.1Tfk Tg(KRT14-cre)1Amc/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:6112650
cn3	Slc39a10^tm1.1Tfk/Slc39a10^tm1.1Tfk Tg(Foxn1-cre)8Ghr/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	MGI:6112651

Genotype
MGI:6112652

cn1

• Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺; Slc39a10^tm1.1Tfk/Slc39a10^tm1.1Tfk
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased pro-B cell number ( J:213935 )

• decrease in B cell progenitors

decreased B cell number ( J:213935 )

• decrease in the number of CD19+ B cells in the spleen

spleen atrophy ( J:213935 )

decreased immunoglobulin level ( J:213935 )

decreased IgA level ( J:213935 )

decreased IgE level ( J:213935 )

decreased IgG1 level ( J:213935 )

decreased IgG2b level ( J:213935 )

decreased IgG2c level ( J:213935 )

decreased IgG3 level ( J:213935 )

decreased IgM level ( J:213935 )

immune system

decreased pro-B cell number ( J:213935 )

• decrease in B cell progenitors

decreased B cell number ( J:213935 )

• decrease in the number of CD19+ B cells in the spleen

spleen atrophy ( J:213935 )

decreased immunoglobulin level ( J:213935 )

decreased IgA level ( J:213935 )

decreased IgE level ( J:213935 )

decreased IgG1 level ( J:213935 )

decreased IgG2b level ( J:213935 )

decreased IgG2c level ( J:213935 )

decreased IgG3 level ( J:213935 )

decreased IgM level ( J:213935 )

Genotype
MGI:6112650

cn2

• Allelic Composition: Slc39a10^tm1.1Tfk/Slc39a10^tm1.1Tfk; Tg(KRT14-cre)1Amc/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

mortality/aging

postnatal lethality, complete penetrance ( J:254216 )

• die within a few days of birth

integument

impaired skin barrier function ( J:254216 )

• particularly in the ventral skin

sparse hair ( J:254216 )

• newborns have thin and feeble hair

decreased hair follicle number ( J:254216 )

• at P1

abnormal epidermal layer morphology ( J:254216 )

• epidermal dysgenesis with dorsal epidermal hypoplasia and ventral embryonic epidermis at P1

abnormal epidermis stratum granulosum morphology ( J:254216 )

• ventral skin lacks a granular layer at P1

thin epidermis stratum granulosum ( J:254216 )

• in the dorsal skin at P1

abnormal epidermis stratum spinosum morphology ( J:254216 )

• ventral skin lacks a spinous layer at P1

thin epidermis ( J:254216 )

• in the dorsal skin the epidermal layer appears atrophic with thinning of the granular layer at P1

reddish skin ( J:254216 )

• newborns have scarlet skin

abnormal skin development ( J:254216 )

• expression analysis indicates a defect in epidermal differentiation

decreased epidermal stem cell number ( J:254216 )

• decrease in the number of Trp63+ epidermal progenitor cells in the hair follicle and interfollicular region at P1

homeostasis/metabolism

impaired skin barrier function ( J:254216 )

• particularly in the ventral skin

Genotype
MGI:6112651

cn3

• Allelic Composition: Slc39a10^tm1.1Tfk/Slc39a10^tm1.1Tfk; Tg(Foxn1-cre)8Ghr/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

immune system

increased thymocyte apoptosis ( J:254216 )

thymus hypoplasia ( J:254216 )

endocrine/exocrine glands

increased thymocyte apoptosis ( J:254216 )

thymus hypoplasia ( J:254216 )

hematopoietic system

increased thymocyte apoptosis ( J:254216 )

thymus hypoplasia ( J:254216 )

cellular

increased thymocyte apoptosis ( J:254216 )