Phenotypes associated with this allele

• Allele Symbol: Map3k15^tm1Hijo
• Allele Name: targeted mutation 1, Hidenori Ichijo
• Allele ID: MGI:5644160
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Map3k15^tm1Hijo/Y	involves: C57BL/6 * ICR	MGI:5688978

Genotype
MGI:5688978

ot1

• Allelic Composition: Map3k15^tm1Hijo/Y
• Genetic Background: involves: C57BL/6 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

abnormal kidney physiology ( J:221240 )

♂ • male hemizygotes exhibit hyperactivation of the SPAK/OSR1 and Na⁺Cl^- cotransporter (NCC) pathway in the distal convoluted tubules of the kidney

cardiovascular system

hypertension ( J:221240 )

♂ • male hemizygotes exhibit a late-onset mild hypertension

salt-sensitive hypertension ( J:221240 )

♂ • at 7, 14 and 21 days after dietary NaCl loading, male hemizygotes show a significantly increased SBP at the age of 13 weeks (i.e. earlier than the spontaneous hypertension), unlike similarly treated wild-type controls where SBP is slightly decreased, as determined by the tail-cuff method

♂ • at day 15 after the start of NaCl loading, male hemizygotes show a significantly higher SBP than wild-type controls in the first half of the dark period, as measured by telemetry

♂ • in contrast, the diastolic blood pressure is modestly, but not significantly elevated at 15 days after the start of NaCl loading

increased systemic arterial systolic blood pressure ( J:221240 )

♂ • male hemizygotes show a significantly increased systolic blood pressure (SBP) along with aging, reaching 115.9 +/- 3.6mmHg at 30 weeks, whereas that of age-matched wild-type controls is only slightly increased (109.3 +/- 1.5mmHg)

♂ • no significant differences in SBP are detected at 14 weeks of age

cellular

abnormal cell physiology ( J:221240 )

♂ • mutant MEFs exposed to hypotonic stress exhibit accelerated activation of oxidative stress-responsive kinase 1 (OSR1)

♂ • hyperactivation of OSR1 in mutant MEFs is suppressed (rescued) by exogenous MAP3K15 expressed via adenovirus infection

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:221240 )

♂N • male hemizygotes display no significant changes in plasma or urine electrolytes (including K+ concentrations) relative to wild-type controls

♂N • no alterations in plasma creatinine and BUN levels or urine creatinine levels are observed