Phenotypes associated with this allele

• Allele Symbol: Dnd1^tm1Na
• Allele Name: targeted mutation 1, Joseph H Nadeau
• Allele ID: MGI:5644313
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Dnd1^tm1Na/Dnd1^+	129S1.129S6-Dnd1^tm1Na	MGI:5696095
ht2	Dnd1^tm1Na/Dnd1^Ter	involves: 129P3/J * 129S6/SvEvTac	MGI:5696097

Genotype
MGI:5696095

ht1

• Allelic Composition: Dnd1^tm1Na/Dnd1⁺
• Genetic Background: 129S1.129S6-Dnd1^tm1Na

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality, incomplete penetrance ( J:221231 )

• 68% of expected heterozygotes in adults

• no homozygotes present

embryonic lethality, incomplete penetrance ( J:221231 )

• no homozygotes found at E3.5

• significantly reduced number of heterozygotes present at E3.5

• reduction in heterozygotes not found in backcrosses

reproductive system

reproductive system phenotype ( J:221231 )

N • litter size is normal despite genotype deficiencies

N • testis weight and germ cell numbers normal

neoplasm

neoplasm ( J:221231 )

N • rate of testicular germ cell tumors similar to controls

Genotype
MGI:5696097

ht2

• Allelic Composition: Dnd1^tm1Na/Dnd1^Ter
• Genetic Background: involves: 129P3/J * 129S6/SvEvTac

mortality/aging

lethality, incomplete penetrance ( J:221231 )

reproductive system

decreased male germ cell number ( J:221231 )

• modestly reduced

decreased testis weight ( J:221231 )

• modestly reduce weight

endocrine/exocrine glands

decreased testis weight ( J:221231 )

• modestly reduce weight

cellular

decreased male germ cell number ( J:221231 )

• modestly reduced