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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dnd1tm1Na
targeted mutation 1, Joseph H Nadeau
MGI:5644313
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Dnd1tm1Na/Dnd1+ 129S1.129S6-Dnd1tm1Na MGI:5696095
ht2
 		Dnd1tm1Na/Dnd1Ter involves: 129P3/J * 129S6/SvEvTac MGI:5696097


Genotype
MGI:5696095
ht1
Allelic
Composition		 Dnd1tm1Na/Dnd1+
Genetic
Background		 129S1.129S6-Dnd1tm1Na
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnd1tm1Na mutation (0 available); any Dnd1 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality, incomplete penetrance ( J:221231 )
• 68% of expected heterozygotes in adults
• no homozygotes present
embryonic lethality, incomplete penetrance ( J:221231 )
• no homozygotes found at E3.5
• significantly reduced number of heterozygotes present at E3.5
• reduction in heterozygotes not found in backcrosses

reproductive system
reproductive system phenotype ( J:221231 )
N
• litter size is normal despite genotype deficiencies
• testis weight and germ cell numbers normal

neoplasm
neoplasm ( J:221231 )
N
• rate of testicular germ cell tumors similar to controls




Genotype
MGI:5696097
ht2
Allelic
Composition		 Dnd1tm1Na/Dnd1Ter
Genetic
Background		 involves: 129P3/J * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnd1Ter mutation (1 available); any Dnd1 mutation (16 available)
Dnd1tm1Na mutation (0 available); any Dnd1 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

reproductive system
decreased male germ cell number ( J:221231 )
• modestly reduced
decreased testis weight ( J:221231 )
• modestly reduce weight

endocrine/exocrine glands
decreased testis weight ( J:221231 )
• modestly reduce weight

cellular
decreased male germ cell number ( J:221231 )
• modestly reduced




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory