Phenotypes associated with this allele

• Allele Symbol: Gipc1^tm1.1Mhsi
• Allele Name: targeted mutation 1.1, Michael Simons
• Allele ID: MGI:5644333
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gipc1^tm1.1Mhsi/Gipc1^tm1.1Mhsi Tg(Tek-cre)12Flv/?	involves: 129S1/SvImJ * 129S4/SvJaeSor * C3H * C57BL/6	MGI:5696327
cn2	Gipc1^tm1.1Mhsi/Gipc1^tm1.1Mhsi Tg(Cdh5-cre/ERT2)1Rha/?	involves: 129S1/SvImJ * 129S4/SvJaeSor * C57BL/6	MGI:5696330
cn3	Gipc1^tm1.1Mhsi/Gipc1^tm1.1Mhsi Tg(Myh11-cre,-EGFP)2Mik/?	involves: 129S1/SvImJ * 129S4/SvJaeSor * C57BL/6 * DBA/2	MGI:5696325

Genotype
MGI:5696327

cn1

• Allelic Composition: Gipc1^tm1.1Mhsi/Gipc1^tm1.1Mhsi; Tg(Tek-cre)12Flv/?
• Genetic Background: involves: 129S1/SvImJ * 129S4/SvJaeSor * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal systemic artery morphology ( J:221554 )

• less arterial branching and fewer collateral arteries in heart and kidney

• significant decrease in smaller arteries

• fewer arteriolar linkages in the spinotrapezius and a more dendritic arterial tree

• narrower input arterioles

coronary artery aneurysm ( J:221554 )

• aneurismal dilations in distal coronary arteries

abnormal blood circulation ( J:221554 )

• impaired recovery of blood flow after hind limb ischemia

Genotype
MGI:5696330

cn2

• Allelic Composition: Gipc1^tm1.1Mhsi/Gipc1^tm1.1Mhsi; Tg(Cdh5-cre/ERT2)1Rha/?
• Genetic Background: involves: 129S1/SvImJ * 129S4/SvJaeSor * C57BL/6

cardiovascular system

abnormal systemic artery morphology ( J:221554 )

• reduced number of collateral arteries

• reduced diameter of input arterioles in the spinotrapezius

abnormal blood circulation ( J:221554 )

• significant decline in blood flow recovery after hind limb ischemia

Genotype
MGI:5696325

cn3

• Allelic Composition: Gipc1^tm1.1Mhsi/Gipc1^tm1.1Mhsi; Tg(Myh11-cre,-EGFP)2Mik/?
• Genetic Background: involves: 129S1/SvImJ * 129S4/SvJaeSor * C57BL/6 * DBA/2

cardiovascular system

cardiovascular system phenotype ( J:221554 )

N • normal arterial tree branching and collateral artery number in the heart and kidney

N • normal spinotrapezius arterial tree

N • blood flow recovery after hindlimb ischemia is similar to controls at 2 weeks

abnormal systemic artery morphology ( J:221554 )

• trend toward fewer small arteries in heart and kidney

• trend toward larger arterial size in hind limbs