All Phenotypes Gpr174<tm1Cys> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Gpr174^tm1Cys/Gpr174⁺	B6.129-Gpr174^tm1Cys	MGI:5644339
cx2	Foxp3^{tm3(HBEGF/GFP)Ayr}/Foxp3⁺ Gpr174^tm1Cys/Gpr174⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:5644340
ot3	Gpr174^tm1Cys/Y	B6.129-Gpr174^tm1Cys	MGI:5644338

Allelic Composition	Gpr174^tm1Cys/Gpr174⁺
Genetic Background	B6.129-Gpr174^tm1Cys

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr174^tm1Cys mutation (0 available); any Gpr174 mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:222307 )

• MOG-treated mice exhibit a modest reduction in disease compared with wild-type mice

Allelic Composition	Foxp3^{tm3(HBEGF/GFP)Ayr}/Foxp3⁺ Gpr174^tm1Cys/Gpr174⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3^{tm3(HBEGF/GFP)Ayr} mutation (2 available); any Foxp3 mutation (58 available)
Gpr174^tm1Cys mutation (0 available); any Gpr174 mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:222307 )

• in mice treated with diphtheria toxin and MOG

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:222307 )

N	• mice exhibit normal numbers of naive T and B cells, lymphoid tissue organization and T or B cell trafficking • mice exhibit normal frequencies of T reg cells in the spleen and lymph nodes • Th17 differentiation is normal

increased T cell proliferation ( J:222307 )

• LysoPS-treated T cells continue to proliferate unlike wild-type cells

• however, OT-II T cells exhibit proliferation after immunization with ovalbumin in alum adjuvant

abnormal T-helper 1 cell differentiation ( J:222307 )

• reduced differentiation even in the absence of exogenous LysoPS

increased single-positive T cell number ( J:222307 )

• increased frequency of Foxp3+ CD4 single positive cells in the thymus and in the colon lamina propria

abnormal regulatory T cell physiology ( J:222307 )

• CD103- regulatory T cells more potently suppress anti-CD3 and dendritic cell-induced proliferation compared with wild-type cells

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:222307 )

• MOG-treated mice exhibit decreased peak disease severity with elevated frequency of CD103+ T reg cells in draining lymph nodes at day 8 to 12 compared with wild-type mice

• however, disease onset is normal

hematopoietic system

increased T cell proliferation ( J:222307 )

• LysoPS-treated T cells continue to proliferate unlike wild-type cells

• however, OT-II T cells exhibit proliferation after immunization with ovalbumin in alum adjuvant

abnormal T-helper 1 cell differentiation ( J:222307 )

• reduced differentiation even in the absence of exogenous LysoPS

increased single-positive T cell number ( J:222307 )

• increased frequency of Foxp3+ CD4 single positive cells in the thymus and in the colon lamina propria

abnormal regulatory T cell physiology ( J:222307 )

• CD103- regulatory T cells more potently suppress anti-CD3 and dendritic cell-induced proliferation compared with wild-type cells

cellular

increased T cell proliferation ( J:222307 )

• LysoPS-treated T cells continue to proliferate unlike wild-type cells

• however, OT-II T cells exhibit proliferation after immunization with ovalbumin in alum adjuvant

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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