Analysis Tools
nervous system
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• homozygotes show a selective increase in fronto-amygdala connectivity relative to wild-type controls
• tract-tracing experiments revealed increased descending projections from the infralimbic (IL) region to basolateral amygdala (BLA), but no differences in ascending projections from BLA to IL
• no differences in descending or ascending projections are noted between the prelimbic (PL) region and BLA
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• following the novelty-induced hypophagia task, homozygotes show a significant reduction in the density of Fos immunoreactive cells in basolateral amygdala, suggesting reduced neural activity in response to a stressful situation
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behavior/neurological
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• in the elevated plus maze test, homozygotes spend a higher % of time in the open arms than wild-type controls, suggesting reduced anxiety-like behavior
• in the novelty-induced hypophagia task, homozygotes trained to approach a reward (sweetened milk) in their home cage display decreased latency to approach and drink milk in a novel environment
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• homozygotes show enhanced cued fear extinction learning, with significantly less freezing behavior (P<0.01) in late extinction trials, but no difference in early trials or in fear acquisition relative to wild-type controls
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homeostasis/metabolism
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• forebrain homogenates from mutant mice exhibit increased anandamide (AEA) levels relative to wild-type controls
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