Analysis Tools
reproductive system
small testis
(
J:220670
)
 |
• males show a small, but significant decrease in testis size relative to wild-type controls
• however, seminiferous tubule structure, sperm morphology and count, and average litter size of studs remain normal
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• at 14 days of age, males exhibit a ~10% decrease in testis weight; this difference is maintained throughout puberty (30 days) to maturity (60 days)
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endocrine/exocrine glands
small testis
(
J:220670
)
|
|
• males show a small, but significant decrease in testis size relative to wild-type controls
• however, seminiferous tubule structure, sperm morphology and count, and average litter size of studs remain normal
|
|
|
• at 14 days of age, males exhibit a ~10% decrease in testis weight; this difference is maintained throughout puberty (30 days) to maturity (60 days)
|
hematopoietic system
| N |
• homozygotes show normal thymus structure, T-cell maturation, spleen development, and blood counts relative to wild-type controls
|
cellular
| N |
• primary MEFs derived from E13.5 embryos show no significant growth defects in the 3T3 proliferation assay
|
