Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tarbp2tm1.1Dzw targeted mutation 1.1, Da-Zhi Wang MGI:5645258 |
||||||||||||
| Summary |
2 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• transgenic expression of Mir208a prevents the onset of dilated cardiomyopathy in cardiac conditional knockouts of Tarbp2 and results in mice with normal heart morphology, histology, and function
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• Although homozygotes are born in normal mendelian ratio indicating no embryonic lethality, more than 80 percent of these cardiac conditional knockout homozygotes die by 4 months of age and none survive beyond 8 months of age
|
|
• although gross morphology of the heart is normal at 2 weeks of age, atrial dilation is found by 3 weeks of age and substantial dilation of both atrial and ventricular chambers is found by 1 month of age and is severe in the homozygotes that survive to 2 months of age, yet cardiomyocyte size appears normal
• neonatal adeno-associated virus-mediated delivery of Tarbp2 or transgenic expression of Mir208a suppresses chamber dilation, permits normal cardiac morphology and restores viability as does knockdown of Sox6, while Tnnt2-dirven viral-mediated overexpression of Sox6 recapitulates the phenotype of cardiac conditional null Tarbp2
|
|
• by 3 weeks of age atrial dilation is found
|
|
• by 1 month of age dilation of the ventricular chambers is also found
|
|
• by 2 weeks of age the left ventricular fractional shortening is decreased and this drops precipitously resulting in severe systolic dysfunction by 1 month of age
|
|
• by 2 weeks of age the left ventricular fractional shortening is decreased and this drops precipitously resulting in severe systolic dysfunction by 1 month of age
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 11/12/2024 MGI 6.24 |
|
|
|
||
