Analysis Tools
mortality/aging
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• the mean longevity of the oldest 20% of mice is increased by 16% in males and 9% in females and the mean longevity of the oldest 10% of mice is also increased
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• early postnatal lethality, with frequency of weaned mice about 50% lower than expected
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growth/size/body
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• mice show a relative decrease in fat mass
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• E13.5 embryos are smaller
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• 27% and 28% decrease in weight of 4-6 month old males and females, respectively
• 35% and 44% decrease in weight of 1-2 year old males and females, respectively
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nervous system
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• the slope of the synaptically evoked field potential is decreased in acute hippocampal slices
• no further depression is seen following synthetic amyloid beta incubation as seen in wild-type hippocampal slices
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adipose tissue
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• subcutaneous (inguinal) white adipose tissue and visceral (epididymal) white adipose tissue shows the presence of abundant brown adipocytes interspersed within white adipocytes
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• mice show a relative decrease in fat mass
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• the interscapular brown adipose tissue shows a more intense color and a denser appearance due to reduced size of the multilocular lipid droplets
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• reduction in size of multilocular lipid droplets in the interscapular brown adipose tissue
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• size of adipocytes in the epididymal white adipose tissue is smaller
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• weight of the epididymal white adipose tissue relative to body weight is lower in males
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• uptake of glucose is higher in the brown adipose tissue of mutants compared to wild-type mice
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• mice exhibit hyperactive brown adipose tissue
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behavior/neurological
polyphagia
(
J:182671
)
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• 1.5-2 year old mice perform better in the tightrope test
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cellular
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• MEFs are more resistant than wild-type MEFs to oncogenic transformation
• marker analysis indicates a lower level of DNA damage in the liver of old mice compared to wild-type mice
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• uptake of glucose is higher in the brown adipose tissue of mutants compared to wild-type mice
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• mouse embryonic fibroblasts (MEFs) exhibit a poorer proliferative capacity compared to wild-type cells
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embryo
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• E13.5 embryos are smaller
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homeostasis/metabolism
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• both young (4-6 months) and old (1.5-2 years) mice exhibit lower fasting levels of glucose
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• both young and old mice exhibit lower insulin serum levels
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• serum levels of Igf1 are moderately lower in both young and old mice
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• serum levels of leptin are reduced
• however, adiponectin and thyroxine levels are normal
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• mice exhibit increased energy expenditure relative to their total body weight and under normal housing conditions
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• both young and old mice exhibit a lower value on the insulin resistance index
• mice fed a high-fat diet for 6 months respond to insulin injection with a significant decrease in glucose levels compared to wild-type mice which are unresponsive to insulin
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• mice exhibit increased resting metabolic rate relative to lean mass, both at 23 and 30 degrees Celcius
• however, locomotor activity, body temperature and respiratory quotient are normal
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• mice intramuscularly injected with 3-methyl-cholanthrene to induce fibrosarcomas show extended tumor-free survival compared to wild-type mice and a reduction in several cancer types, notably lymphomas and histiocytic sarcomas
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liver/biliary system
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• high-fat diet fed mice are protected from liver steatosis
• however, high-fat diet fed mice increase body weight similarly to wild-type mice
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neoplasm
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• mice intramuscularly injected with 3-methyl-cholanthrene to induce fibrosarcomas show extended tumor-free survival compared to wild-type mice and a reduction in several cancer types, notably lymphomas and histiocytic sarcomas
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