All Phenotypes Ddt<tm1Lhy> MGI Mouse

cardiovascular system phenotype ( J:213776 )

N	• mice exhibit normal baseline cardiac morphology and histology, with intact left ventricle size, wall thickness, and ejection fraction, and normal left ventricle contractile function ex vivo

cardiac muscle necrosis ( J:213776 )

• hearts exposed to ischemia-reperfusion exhibit 2.3-fold more necrosis than controls

• mice subjected to transient left coronary artery ligation followed by reperfusion show a 3.5-fold greater necrosis in the left ventricle

decreased heart left ventricle muscle contractility ( J:213776 )

• left ventricle fractional shortening is 50% lower than in controls after ischemia-reperfusion

increased susceptibility to myocardial ischemic injury ( J:213776 )

• hearts exposed to ischemia-reperfusion show exacerbated left ventricle contractile dysfunction, with less recovery of the left ventricular developed pressure-heart rate index and other parameters of left ventricle contractile function, and increase in necrosis

• mice subjected to transient left coronary artery ligation followed by reperfusion show more severe cardiac injury than controls, with 3.5-fold greater necrosis in left ventricle and 2.5-fold higher serum troponin release

• recovery of contractile function and extent of injury after ischemia-reperfusion is similar to wild-type mice after perfusion with recombinant DTT

increased myocardial infarct size ( J:213776 )

• infract size is greater in isolated perfused hearts during reperfusion after ischemia than in wild-type hearts