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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gpr107tm1Brs
targeted mutation 1, Brian Seed
MGI:5645975
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gpr107tm1Brs/Gpr107tm1Brs involves: 129S6/SvEvTac MGI:5766998


Genotype
MGI:5766998
hm1
Allelic
Composition
Gpr107tm1Brs/Gpr107tm1Brs
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr107tm1Brs mutation (1 available); any Gpr107 mutation (125 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygous mutant embryos suffer a catastrophic event and die between E11.5 and E12.5
• lethality is associated with loss of cubilin protein expression and decreased expression of multiple genes implicated in the cubilin-megalin multi-ligand endocytic receptor complex at E10.5

growth/size/body
• at E10.5, a small number of homozygous mutant embryos exhibit reduced size but are otherwise normal

embryo
• at E10.5, a small number of homozygous mutant embryos exhibit reduced size but are otherwise normal

cellular
• MEFs derived from E10.5 mutant embryos exhibit defects in transferrin internalization, uptake of low-density lipoprotein (LDL) receptor-related protein-1 (LRP1) cargo, and integrin alpha5-mediated fibronectin secretion
• mutant MEFs are resistant to LRP1-dependent cholix toxin cytotoxicity and internalize LDL poorly





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory