Phenotypes associated with this allele

• Allele Symbol: Fastkd5^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5646000
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fastkd5^tm1.1(KOMP)Vlcg/Fastkd5^tm1.1(KOMP)Vlcg	B6N(Cg)-Fastkd5^tm1.1(KOMP)Vlcg/J	MGI:6262420
hm2	Fastkd5^tm1.1(KOMP)Vlcg/Fastkd5^tm1.1(KOMP)Vlcg	C57BL/6N-Fastkd5^tm1.1(KOMP)Vlcg/JMmucd	MGI:7736598

Genotype
MGI:6262420

hm1

• Allelic Composition: Fastkd5^{tm1.1(KOMP)Vlcg}/Fastkd5^{tm1.1(KOMP)Vlcg}
• Genetic Background: B6N(Cg)-Fastkd5^{tm1.1(KOMP)Vlcg}/J
• Cell Lines: 11301B-D4

Data Sources

IMPC Data for Fastkd5

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to tooth bud stage ( J:211773 )

IMPC - JAX

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

Genotype
MGI:7736598

hm2

• Allelic Composition: Fastkd5^{tm1.1(KOMP)Vlcg}/Fastkd5^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Fastkd5^{tm1.1(KOMP)Vlcg}/JMmucd
• Cell Lines: 11301B-D4

Fastkd5^{tm1.1(KOMP)Vlcg}/Fastkd5^{tm1.1(KOMP)Vlcg} mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos are smaller and form a rudimentary egg cylinder but no primitive streak or hallmarks of gastrulation are seen at E7.5.

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:279207 )

• homozygous embryos are recovered in expected Mendelian ratios at E7.5 but arrest prior to gastrulation; no homozygous embryos are recovered at E9.5

embryo

failure to gastrulate ( J:290315 , J:279207 )

• no hallmarks typical of gastrulating embryos are observed at E7.5 (J:279207)

embryonic growth arrest ( J:279207 )

• embryos arrest prior to gastrulation

decreased embryo size ( J:279207 )

• embryos are smaller than controls at E7.5

decreased egg cylinder size ( J:279207 )

• a rudimentary egg cylinder is observed at E7.5

absent head fold ( J:279207 )

• no head folds are present at E7.5

absent primitive node ( J:279207 )

• no embryonic node is present at E7.5

failure of primitive streak formation ( J:279207 )

• no morphological evidence of primitive streak formation is observed at E7.5

growth/size/body

decreased embryo size ( J:279207 )

• embryos are smaller than controls at E7.5