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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ank2tm2.1Bnt
targeted mutation 2.1, Vann Bennett
MGI:5646021
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ank2tm2.1Bnt/Ank2tm2.1Bnt STOCK Ank2tm2Bnt/J MGI:5646179
ht2
Ank2tm2.1Bnt/Ank2+ STOCK Ank2tm2Bnt/J MGI:5646180


Genotype
MGI:5646179
hm1
Allelic
Composition
Ank2tm2.1Bnt/Ank2tm2.1Bnt
Genetic
Background
STOCK Ank2tm2Bnt/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ank2tm2.1Bnt mutation (0 available); any Ank2 mutation (185 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• after oral glucose administration, mice exhibit normal insulin secretion and serum levels
• at 3 and 10 months, mice exhibit normal energy expenditure, oxygen consumption and respiratory quotient
• in mice are fed a high-fat diet
• during an oral glucose tolerance test in mice fed normal chow
• in fasted mice fed a high-fat diet
• at 3 months, mice exhibit a decrease in hepatic endogenous glucose production compared with wild-type mice
• delayed glucose clearance during an oral glucose tolerance test in mice fed normal chow
• in mice fed a high-fat diet
• however, glucose tolerance is administered through intraperitoneal injection
• in mice are fed a high-fat diet

liver/biliary system

adipose tissue
• mouse embryonic fibroblasts exhibit increased adipogenesis with both increased in adipocyte numbers and enlarged lipid droplets compared with wild-type cells.
• modestly increased in white adipose tissue

cellular
• mouse embryonic fibroblasts exhibit increased adipogenesis with both increased in adipocyte numbers and enlarged lipid droplets compared with wild-type cells.
• modestly increased in white adipose tissue

growth/size/body
• at 10 months, but not at 3 months, in mice fed normal chow
• in mice fed a high-fat diet
• in mice are fed a high-fat diet

behavior/neurological
N
• at 3 and 10 months, mice exhibit normal activity and appetite

muscle
N
• skeletal muscles exhibit normal glucose uptake




Genotype
MGI:5646180
ht2
Allelic
Composition
Ank2tm2.1Bnt/Ank2+
Genetic
Background
STOCK Ank2tm2Bnt/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ank2tm2.1Bnt mutation (0 available); any Ank2 mutation (185 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median survival of 855 days compared with 896 days for wild-type mice

homeostasis/metabolism





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory