Analysis Tools
homeostasis/metabolism
| N |
• at 3 and 10 months, mice exhibit normal energy expenditure, oxygen consumption and respiratory quotient
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• in mice fed a high-fat diet
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• at 3 months, mice exhibit increased glucose utilization compared with wild-type mice
• mice exhibit higher whole-body glucose disposal compared with wild-type mice
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• following glucose ingestion
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• during an oral glucose tolerance test in mice fed normal chow
• in fasted mice fed a high-fat diet
• at 10 months in fasted mice fed normal chow
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• following glucose ingestion
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• at 3 months, mice exhibit a decrease in hepatic endogenous glucose production compared with wild-type mice
• at 10 months, mice exhibit a increase in hepatic endogenous glucose production compared with wild-type mice
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• delayed glucose clearance during an oral glucose tolerance test in mice fed normal chow
• in mice fed a high-fat diet at 10 months
• in fasted mice fed normal chow
• however, glucose tolerance is administered through intraperitoneal injection
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• in mice are fed a high-fat diet
• at 10 months in fasted mice fed normal chow
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liver/biliary system
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• in mice are fed a high-fat diet
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endocrine/exocrine glands
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• following glucose ingestion
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adipose tissue
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• age-dependent at 10 months
• however, adiposity at 3 months is normal
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• mouse embryonic fibroblasts exhibit increased adipogenesis with both increased in adipocyte numbers and enlarged lipid droplets compared with wild-type cells.
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• in mice are fed a high-fat diet
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• decreased in white adipose tissue at 10 months
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• increased in white adipose tissue at 3 months
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growth/size/body
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• at 10 months, but not at 3 months, in mice fed normal chow
• in mice fed a high-fat diet
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• in mice fed a high-fat diet
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cellular
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• mouse embryonic fibroblasts exhibit increased adipogenesis with both increased in adipocyte numbers and enlarged lipid droplets compared with wild-type cells.
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• decreased in white adipose tissue at 10 months
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• increased in white adipose tissue at 3 months
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• decreased glucose uptake in skeletal muscle in mice at 10 months
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• increased glucose uptake in skeletal muscle in mice at 3 months
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behavior/neurological
| N |
• at 3 and 10 months, mice exhibit normal activity and appetite
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muscle
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• decreased glucose uptake in skeletal muscle in mice at 10 months
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• increased glucose uptake in skeletal muscle in mice at 3 months
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