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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Srxn1tm1Sgrh
targeted mutation 1, Sue Goo Rhee
MGI:5646116
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Srxn1tm1Sgrh/Srxn1tm1Sgrh
Tg(Cyp11a1-cre)16Mchu/?
involves: C57BL/6J MGI:5693737


Genotype
MGI:5693737
cn1
Allelic
Composition
Srxn1tm1Sgrh/Srxn1tm1Sgrh
Tg(Cyp11a1-cre)16Mchu/?
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srxn1tm1Sgrh mutation (0 available); any Srxn1 mutation (9 available)
Tg(Cyp11a1-cre)16Mchu mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• less increase in corticosterone levels in response to ACTH
• plasma levels significantly reduced
• daily oscillation in corticosterone level persists but at a lower level
• circulating ACTH levels increased 80%

endocrine/exocrine glands
• cholesterol accumulation in steroidogenic cells
• increased number and size of vacuoles containing neutral lipids
• hyperplasia
• impaired steroidogenesis





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory