Phenotypes associated with this allele

• Allele Symbol: Tg(Thy1-PSEN1*M146V)#Jiri
• Allele Name: transgene insertion, Jill C Richardson
• Allele ID: MGI:5646170
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Thy1-APPSw)10Jiri/0 Tg(Thy1-PSEN1*M146V)#Jiri/0	B6.Cg-Tg(Thy1-APPSw)10Jiri Tg(Thy1-PSEN1*M146V)#Jiri	MGI:5646215
cx2	Tg(Thy1-APPSw)10Jiri/0 Tg(Thy1-PSEN1*M146V)#Jiri/0	involves: C3H * C57BL/6	MGI:5646171

Genotype
MGI:5646215

cx1

• Allelic Composition: Tg(Thy1-APPSw)10Jiri/0; Tg(Thy1-PSEN1*M146V)#Jiri/0
• Genetic Background: B6.Cg-Tg(Thy1-APPSw)10Jiri Tg(Thy1-PSEN1*M146V)#Jiri

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

amyloidosis ( J:156577 )

• marked amyloidosis in the thalamus, hippocampal formation and cerebral cortex

amyloid beta deposits ( J:156577 )

• amyloid beta deposition that appears first at about 3-4 months of age

nervous system

microgliosis ( J:156577 )

• stellate microgliosis appears from about 5-6 months of age where plaque is increasingly deposited

amyloid beta deposits ( J:156577 )

• amyloid beta deposition that appears first at about 3-4 months of age

increased brain size ( J:156577 )

• the brain and its component regions grow more than in wild-type mice from 6-14 months of age (5.1% vs 2.8% in wild-type), showing an increase in volume and size over time; this may be due to the progressive amyloid deposition and astrogliosis

• thalamus, cerebellum, cerebral cortex, and caudoputamen are proportionally larger from an early age in mutants than in wild-type mice but they show a relative decline with age

• thalamus and caudoputamen decline in relative volume faster than in wild-type mice, although cerebral cortex declines less rapidly

• corpus callosum, corticospinal tract, hypothalamus, midbrain-hindbrain and fornix system account for a smaller proportion of the brain, although they progressively enlarge with age similarly to wild-type mice

abnormal corpus callosum morphology ( J:156577 )

• corpus callosum makes up a smaller proportion of the brain than in wild-type mice, however it progressively enlarges with age

abnormal putamen morphology ( J:156577 )

• decrease in caudoputamen size over time (-2.8% vs. 0.1% in wild-type), even though the caudoputamen is proportionally larger at an early age in mutants than in wild-type mice

abnormal hypothalamus morphology ( J:156577 )

• the hypothalamus makes up a smaller proportion of the brain than in wild-type mice, however it progressively enlarges with age

abnormal thalamus morphology ( J:156577 )

• thalamus is larger in mutants at an early age compared to wild-type mice, however the thalamus declines in relative volume faster than in wild-type mice with age

enlarged hippocampus ( J:156577 )

• hippocampal formation size is increased by about 11% over 8 months compared to about 0.3% in wild-type mice

abnormal cerebral cortex morphology ( J:156577 )

• a 2.4% increase in cerebral cortex size compared to a -0.4% decrease in wild-type mice over time

enlarged cerebellum ( J:156577 )

• cerebellum is larger in mutants at an early age compared to wild-type mice, however a decline in size is seen with age as in wild-type mice

astrocytosis ( J:156577 )

• astrogliosis in the cerebral cortex, thalamus, and hippocampal formation at 9-14 months of age

abnormal corticospinal tract morphology ( J:156577 )

• the corticospinal tract makes up a smaller proportion of the brain than in wild-type mice, however it progressively enlarges with age

hematopoietic system

microgliosis ( J:156577 )

• stellate microgliosis appears from about 5-6 months of age where plaque is increasingly deposited

immune system

microgliosis ( J:156577 )

• stellate microgliosis appears from about 5-6 months of age where plaque is increasingly deposited

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:156577

Genotype
MGI:5646171

cx2

• Allelic Composition: Tg(Thy1-APPSw)10Jiri/0; Tg(Thy1-PSEN1*M146V)#Jiri/0
• Genetic Background: involves: C3H * C57BL/6

behavior/neurological

abnormal object recognition memory ( J:91273 )

• in the object recognition test, mice exhibit lower recognition indices than wild-type mice at 6, 8, and 10 months of age, but not at 3 or 4 months of age

homeostasis/metabolism

amyloid beta deposits ( J:91273 , J:222897 )

• amyloid beta deposits are first seen in the brain at 3 months of age (J:91273)

• amyloid beta load is greater in females than males (J:91273)

• all mice exhibit cerebral amyloid beta deposits at 4 months of age with levels increasing significantly between 6 and 10 months of age (J:91273)

• amyloid beta deposits are seen in the cerebrovasculature (J:91273)

• extracellular fibrillar amyloid beta plaques are seen in the cerebral cortex from 6 months of age, most prevalent in the infragranular layers, and density increases with age (J:91273)

nervous system

amyloid beta deposits ( J:91273 , J:222897 )

• amyloid beta deposits are first seen in the brain at 3 months of age (J:91273)

• amyloid beta load is greater in females than males (J:91273)

• all mice exhibit cerebral amyloid beta deposits at 4 months of age with levels increasing significantly between 6 and 10 months of age (J:91273)

• amyloid beta deposits are seen in the cerebrovasculature (J:91273)

• extracellular fibrillar amyloid beta plaques are seen in the cerebral cortex from 6 months of age, most prevalent in the infragranular layers, and density increases with age (J:91273)

abnormal neurite morphology ( J:91273 )

• cortical plaques are surrounded by clusters of dystrophic neurites

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:222897