Phenotypes associated with this allele

• Allele Symbol: Mrgpre^tm1Dgen
• Allele Name: targeted mutation 1, Deltagen
• Allele ID: MGI:5646195
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mrgpre^tm1Dgen/Mrgpre^tm1Dgen	involves: 129P2/OlaHsd * C57BL/6J	MGI:5661346

Genotype
MGI:5661346

hm1

• Allelic Composition: Mrgpre^tm1Dgen/Mrgpre^tm1Dgen
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:222382 )

N • homozygotes are overtly normal and show no differences in general motor coordination relative to wild-type controls

N • no significant difference in the frequency or timing of nocifensive behaviors was noted in the first or second phase of the formalin test, indicating a normal pain response to a noxious chemical stimulus

N • hot plate behavior is normal, indicating a normal pain response to an acute thermal stimulus

allodynia ( J:222382 )

• no differences in the onset of recovery are observed relative to wild-type controls (~100 days post-surgery)

• however, homozygotes maintain a normal level of allodynia, as determined by a paw withdrawal threshold of 0.04 g or less

• after chronic constriction injury of the sciatic nerve, homozygotes show a delay in the onset of maximal allodynia, with the most significant difference noted in the day 2 to 7 period post-surgery