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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Klhl3tm1.1Esoh
targeted mutation 1.1, Eisei Sohara
MGI:5646378
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Klhl3tm1.1Esoh/Klhl3tm1.1Esoh involves: C57BL/6 MGI:5646379
ht2
 		Klhl3tm1.1Esoh/Klhl3+ involves: C57BL/6 MGI:5646380


Genotype
MGI:5646379
hm1
Allelic
Composition		 Klhl3tm1.1Esoh/Klhl3tm1.1Esoh
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klhl3tm1.1Esoh mutation (0 available); any Klhl3 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
salt-sensitive hypertension ( J:214330 )
• significantly greater increase in systolic blood pressure on a high salt diet
• blood pressure on a normal salt diet is similar to controls

homeostasis/metabolism




Genotype
MGI:5646380
ht2
Allelic
Composition		 Klhl3tm1.1Esoh/Klhl3+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klhl3tm1.1Esoh mutation (0 available); any Klhl3 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
salt-sensitive hypertension ( J:214330 )
• blood pressure on a normal salt diet is similar to controls
• significantly greater increase in systolic blood pressure on a high salt diet

homeostasis/metabolism

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
pseudohypoaldosteronism DOID:4479 J:214330




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory