Phenotypes associated with this allele

• Allele Symbol: Dohh^tm1.1Sbal
• Allele Name: targeted mutation 1.1, Stefan Balabanov
• Allele ID: MGI:5646512
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Dohh^tm1.1Sbal/Dohh^tm1.1Sbal Tg(CAG-cre/Esr1*)5Amc/0	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ	MGI:5903288

Genotype
MGI:5903288

cn1

• Allelic Composition: Dohh^tm1.1Sbal/Dohh^tm1.1Sbal; Tg(CAG-cre/Esr1*)5Amc/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:236582 )

• 1 to 5 weeks after tamoxifen treatment

growth/size/body

decreased body weight ( J:236582 )

• in tamoxifen-treated mice

cachexia ( J:236582 )

• in tamoxifen-treated mice due to wasting syndrome

renal/urinary system

increased kidney iron level ( J:236582 )

• enhanced ferrous iron incorporation in the kidney of 2 of 4 tamoxifen-treated mice

renal tubular necrosis ( J:236582 )

• in one tamoxifen-treated mouse

liver/biliary system

hepatic necrosis ( J:236582 )

• in two tamoxifen-treated mice

focal hepatic necrosis ( J:236582 )

• diffuse in one tamoxifen-treated mouse

homeostasis/metabolism

increased kidney iron level ( J:236582 )

• enhanced ferrous iron incorporation in the kidney of 2 of 4 tamoxifen-treated mice

hematopoietic system

hematopoietic system phenotype ( J:236582 )

N • tamoxifen-treated mice exhibit normal bone marrow cellularity