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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dohhtm1.2Sbal
targeted mutation 1.2, Stefan Balabanov
MGI:5646515
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dohhtm1.2Sbal/Dohhtm1.2Sbal B6.129(Cg)-Dohhtm1.2Sbal MGI:5646517
ht2
 		Dohhtm1.2Sbal/Dohh+ B6.129(Cg)-Dohhtm1.2Sbal MGI:5646518


Genotype
MGI:5646517
hm1
Allelic
Composition		 Dohhtm1.2Sbal/Dohhtm1.2Sbal
Genetic
Background		 B6.129(Cg)-Dohhtm1.2Sbal
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dohhtm1.2Sbal mutation (0 available); any Dohh mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality prior to organogenesis, complete penetrance ( J:214321 )
• all die after E4.5 but well before E9.5




Genotype
MGI:5646518
ht2
Allelic
Composition		 Dohhtm1.2Sbal/Dohh+
Genetic
Background		 B6.129(Cg)-Dohhtm1.2Sbal
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dohhtm1.2Sbal mutation (0 available); any Dohh mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal spleen morphology ( J:214321 )
• a diffuse infiltration of the spleen with a homogenous, probably lymphoid, cell population was seen in 3 mice
• however, no significant hematological abnormalities are seen in young or adult mice

immune system
abnormal spleen morphology ( J:214321 )
• a diffuse infiltration of the spleen with a homogenous, probably lymphoid, cell population was seen in 3 mice
• however, no significant hematological abnormalities are seen in young or adult mice




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory