Analysis Tools
growth/size/body
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• newborn mice are smaller than littermates
• adult mice are slightly (but significantly) smaller than wild-type mice
|
weight loss
(
J:198414
)
|
• mice lose less body weight following bleomycin treatment as compared to wild-type
|
|
• lung weight increases but less than that of wild-type mice following bleomycin treatment
|
homeostasis/metabolism
|
• all mice survive bleomycin treatment; 25% of wild-type mice die
|
|
• mice exhibit resistance to bleomycin-induced lung fibrosis as compared to wild-type
• mice lose less body weight following bleomycin treatment as compared to wild-type
• lung weight increases but less than that of wild-type mice following bleomycin treatment
• some mice have normal lungs, others show limited areas of fibrosis following bleomycin treatment
|
mortality/aging
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• all mice survive bleomycin treatment; 25% of wild-type mice die
|
|
• heterozygote x heterozygote matings produce fewer homozygotes than expected
|
respiratory system
|
• lung weight increases but less than that of wild-type mice following bleomycin treatment
|
|
• some mice have normal lungs, others show limited areas of fibrosis following bleomycin treatment
|
