Phenotypes associated with this allele

• Allele Symbol: Tg(SFTPC*)#Twv
• Allele Name: transgene insertion, Timothy E Weaver
• Allele ID: MGI:5647890
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(SFTPC*)#Twv/0	FVB/N-Tg(SFTPC*)#Twv	MGI:5647902

Genotype
MGI:5647902

tg1

• Allelic Composition: Tg(SFTPC*)#Twv/0
• Genetic Background: FVB/N-Tg(SFTPC*)#Twv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:87084 )

respiratory system

abnormal branching involved in lung morphogenesis ( J:87084 )

• impaired branching morphogenesis

abnormal lung saccule morphology ( J:87084 )

• cystic saccules

abnormal pulmonary alveolus epithelial cell morphology ( J:87084 )

• vacuolated and hypertrophic lung epithelial cells

pulmonary hypoplasia ( J:87084 )

• lung tissue from the most severely affected animal was extremely hypoplastic

abnormal respiratory conducting tube morphology ( J:87084 )

• a significant amount of debris in the proximal and distal airways which consisted of sloughed epithelial cells and macrophages recruited into the air spaces