Analysis Tools
reproductive system
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• increased accumulation of collagen fibers around blood vessels in affected ovaries
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• at 4 to 14 months of age, ~30% of nulliparous females show dramatically enlarged, edematous ovaries with a significantly increased diameter
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ovary cyst
(
J:214298
)
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• spontaneous ovarian cysts in 30% of females, suggesting increased vascular permeability
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• large cystic follicles due to edema formation
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• in some cases, abnormal accumulation of collagen fibers is seen in the basal lamina of ovarian capillaries although general organization of the capillaries is normal
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• extensive disorganization of the myometrium and endometrium with highly edematous uterine glands, numerous areas with sparse cells (ASCs) throughout the uterus, and increased accumulation of collagen fibers around blood vessels
• ASCs show a reduction in blood vessel number consistent with the decrease in overall cell density
• only a few blood vessels are present in large ASCs, indicating that all stromal cells disappear
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• highly edematous uterine glands in affected females
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• at 4 to 14 months of age, ~30% of nulliparous females show an enlarged, edematous uterus with a significantly increased diameter
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• dramatic accumulation of collagen fibers around blood vessels and capillaries within areas with sparse cells (ASCs)
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homeostasis/metabolism
cardiovascular system
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• EM analysis of ovarian capillaries showed a slight but significant increase in the gap size between two adjacent endothelial cell membranes in endothelial cell junctions
• in few cases (<2%), some continuities between the lumen of the ovarian capillary and the basal lamina are observed
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• edema formation and fibrosis around blood vessels in the uterus and ovaries of affected females, indicating increased sensitivity to vascular permeability
• increased basal capillary permeability in the skin of male mice, as quantified by spontaneous Evans Blue (EB) leakage
• increased VEGF-induced EB incorporation in the skin of male mice, as determined by a Miles assay
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endocrine/exocrine glands
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• highly edematous uterine glands in affected females
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|
|
• increased accumulation of collagen fibers around blood vessels in affected ovaries
|
|
|
• at 4 to 14 months of age, ~30% of nulliparous females show dramatically enlarged, edematous ovaries with a significantly increased diameter
|
ovary cyst
(
J:214298
)
|
|
• spontaneous ovarian cysts in 30% of females, suggesting increased vascular permeability
|
|
|
• large cystic follicles due to edema formation
|
|
|
• in some cases, abnormal accumulation of collagen fibers is seen in the basal lamina of ovarian capillaries although general organization of the capillaries is normal
|
growth/size/body
|
|
• at 4 to 14 months of age, ~30% of nulliparous females show dramatically enlarged, edematous ovaries with a significantly increased diameter
|
ovary cyst
(
J:214298
)
|
|
• spontaneous ovarian cysts in 30% of females, suggesting increased vascular permeability
|
|
|
• large cystic follicles due to edema formation
|
