Phenotypes associated with this allele

• Allele Symbol: Pde4b^enu1H
• Allele Name: mutation 1, Harwell
• Allele ID: MGI:5648042
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pde4b^enu1H/Pde4b^enu1H	B6.C(C3H)-Pde4b^enu1H	MGI:5648933
cx2	Pde4b^enu1H/Pde4b^enu1H Tg(Thy1-EGFP)#Jrs/0	involves: BALB/cAnN * C3H/HeH * C57BL/6 * CBA	MGI:5648931

Genotype
MGI:5648933

hm1

• Allelic Composition: Pde4b^enu1H/Pde4b^enu1H
• Genetic Background: B6.C(C3H)-Pde4b^enu1H

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:223217 )

N • mice exhibit normal behavior in a forced swim test, normal contextual conditioning and normal nociception

abnormal learning/memory/conditioning ( J:223217 )

• in a social recognition test, mice exhibit enhanced long-term memory compared with wild-type mice

impaired cued conditioning behavior ( J:223217 )

• decreased freezing

abnormal object recognition memory ( J:223217 )

• in a typical room lighting and under adverse dim lighting, mice exhibit preference for a displaced objects after 5 minutes unlike wild-type mice

increased exploration in new environment ( J:223217 )

• in an elevated plus maze, mice spend more time in open arms and make more exploratory compared with wild-type mice

• in an open field, mice display greater ambulation and rearing activity compared with wild-type mice

• in a holeboard test, mice exhibit greater exploratory burrowing compared with wild-type mice

enhanced spatial working memory ( J:223217 )

• improved spatial memory in a Morris water maze in both the acquisition and reversal training trials

enhanced learning ( J:223217 )

decreased anxiety-related response ( J:223217 )

• in an elevated plus maze, mice spend more time in open arms compared with wild-type mice

• in an open field, mice spend more time in the center compared with wild-type mice

• in a light-dark box, mice spend more time in the bright compartment compared with wild-type mice

• in a T maze with food pellets and bob-cat urine, mice spend equal time exploring both arms unlike wild-type mice

increased vertical activity ( J:223217 )

• in an open field

nervous system

nervous system phenotype ( J:223217 )

N • mice exhibit normal basal synaptic transmission and paired-pulse facilitation

abnormal neuron differentiation ( J:223217 )

• increased neurogenesis in the hippocampal dentate gyrus following fear conditioning

abnormal CNS synaptic transmission ( J:223217 )

• enhanced potentiation following forskolin application

enhanced long-term potentiation ( J:223217 )

increased post-tetanic potentiation ( J:223217 )

decreased synaptic depression ( J:223217 )

• following low frequency stimulation, mice exhibit less synaptic depression compared with wild-type mice

• however, synaptic depression after 900 pulses of 1-Hz stimulation is normal

taste/olfaction

taste/olfaction phenotype ( J:223217 )

N • mice exhibit normal olfaction

cellular

abnormal neuron differentiation ( J:223217 )

• increased neurogenesis in the hippocampal dentate gyrus following fear conditioning

Genotype
MGI:5648931

cx2

• Allelic Composition: Pde4b^enu1H/Pde4b^enu1H; Tg(Thy1-EGFP)#Jrs/0
• Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6 * CBA

nervous system

increased dendritic spine density ( J:223217 )

• increased spine density in the hippocampus and lateral amygdala