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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(tetO-Hgf,-EGFP)24Tcre
transgene insertion 24, Tiziana Crepaldi
MGI:5648118
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Cdkn2atm1Cjs/Cdkn2atm1Cjs
Pax7tm1Pgr/Pax7tm1Pgr
Tg(CKMM-tTA)A3Rhvh/0
Tg(tetO-Hgf,-EGFP)24Tcre/0 		involves: 129S2/SvPas * 129X1/SvJ * FVB MGI:5882413
cx2
 		Cdkn2atm1Cjs/Cdkn2atm1Cjs
Pax7tm1Pgr/Pax7+
Tg(CKMM-tTA)A3Rhvh/0
Tg(tetO-Hgf,-EGFP)24Tcre/0 		involves: 129S2/SvPas * 129X1/SvJ * FVB MGI:5882414
cx3
 		Cdkn2atm1Cjs/Cdkn2atm1Cjs
Tg(CKMM-tTA)A3Rhvh/0
Tg(tetO-Hgf,-EGFP)24Tcre/0 		involves: 129X1/SvJ * FVB MGI:5882410
cx4
 		Cdkn2atm1Cjs/Cdkn2a+
Tg(CKMM-tTA)A3Rhvh/0
Tg(tetO-Hgf,-EGFP)24Tcre/0 		involves: 129X1/SvJ * FVB MGI:5882411
cx5
 		Tg(CKMM-tTA)A3Rhvh/0
Tg(tetO-Hgf,-EGFP)24Tcre/0 		involves: FVB MGI:5882409


Genotype
MGI:5882413
cx1
Allelic
Composition		 Cdkn2atm1Cjs/Cdkn2atm1Cjs
Pax7tm1Pgr/Pax7tm1Pgr
Tg(CKMM-tTA)A3Rhvh/0
Tg(tetO-Hgf,-EGFP)24Tcre/0
Genetic
Background		 involves: 129S2/SvPas * 129X1/SvJ * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Cjs mutation (6 available); any Cdkn2a mutation (62 available)
Pax7tm1Pgr mutation (1 available); any Pax7 mutation (39 available)
Tg(CKMM-tTA)A3Rhvh mutation (2 available)
Tg(tetO-Hgf,-EGFP)24Tcre mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
increased rhabdomyosarcoma incidence ( J:237183 )
• 29% of tumors are embryonal rhabdomyosarcoma

neoplasm
increased sarcoma incidence ( J:237183 )
• 87% of mice develop sarcomas
• 71% of tumors that form in mice are undifferentiated pleomorphic sarcoma
increased rhabdomyosarcoma incidence ( J:237183 )
• 29% of tumors are embryonal rhabdomyosarcoma




Genotype
MGI:5882414
cx2
Allelic
Composition		 Cdkn2atm1Cjs/Cdkn2atm1Cjs
Pax7tm1Pgr/Pax7+
Tg(CKMM-tTA)A3Rhvh/0
Tg(tetO-Hgf,-EGFP)24Tcre/0
Genetic
Background		 involves: 129S2/SvPas * 129X1/SvJ * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Cjs mutation (6 available); any Cdkn2a mutation (62 available)
Pax7tm1Pgr mutation (1 available); any Pax7 mutation (39 available)
Tg(CKMM-tTA)A3Rhvh mutation (2 available)
Tg(tetO-Hgf,-EGFP)24Tcre mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
increased rhabdomyosarcoma incidence ( J:237183 )
• mice develop mainly embryonal rhabdomyosarcoma, with 92% of tumors being embryonal rhabdomyosarcoma

neoplasm
increased sarcoma incidence ( J:237183 )
• 100% of mice develop sarcoma
• 8% of tumors are undifferentiated pleomorphic sarcoma
increased rhabdomyosarcoma incidence ( J:237183 )
• mice develop mainly embryonal rhabdomyosarcoma, with 92% of tumors being embryonal rhabdomyosarcoma




Genotype
MGI:5882410
cx3
Allelic
Composition		 Cdkn2atm1Cjs/Cdkn2atm1Cjs
Tg(CKMM-tTA)A3Rhvh/0
Tg(tetO-Hgf,-EGFP)24Tcre/0
Genetic
Background		 involves: 129X1/SvJ * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Cjs mutation (6 available); any Cdkn2a mutation (62 available)
Tg(CKMM-tTA)A3Rhvh mutation (2 available)
Tg(tetO-Hgf,-EGFP)24Tcre mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
skeletal muscle hyperplasia ( J:237183 )
• 32% of mice that develop embryonal rhabdomyosarcoma exhibit muscle hyperplasia while 68% of mice develop embryonal rhabdomyosarcoma without muscle hyperplasia
increased rhabdomyosarcoma incidence ( J:237183 )
• all mice develop tumors, mainly multi-step embryonal rhabdomyosarcoma with a short latency of 3.95 months
• embryonal rhabdomyosarcoma originates from satellite cells
• treatment of mice with doxycycline when tumors become palpable does not impair tumor growth
• mice maintained under doxycycline treatment until P10 develop tumors after doxycycline removal

neoplasm
increased rhabdomyosarcoma incidence ( J:237183 )
• all mice develop tumors, mainly multi-step embryonal rhabdomyosarcoma with a short latency of 3.95 months
• embryonal rhabdomyosarcoma originates from satellite cells
• treatment of mice with doxycycline when tumors become palpable does not impair tumor growth
• mice maintained under doxycycline treatment until P10 develop tumors after doxycycline removal

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
embryonal rhabdomyosarcoma DOID:3246 OMIM:268210
 J:237183




Genotype
MGI:5882411
cx4
Allelic
Composition		 Cdkn2atm1Cjs/Cdkn2a+
Tg(CKMM-tTA)A3Rhvh/0
Tg(tetO-Hgf,-EGFP)24Tcre/0
Genetic
Background		 involves: 129X1/SvJ * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Cjs mutation (6 available); any Cdkn2a mutation (62 available)
Tg(CKMM-tTA)A3Rhvh mutation (2 available)
Tg(tetO-Hgf,-EGFP)24Tcre mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
increased rhabdomyosarcoma incidence ( J:237183 )
• mice develop multi-step embryonal rhabdomyosarcoma with a latency of 6 months
• majority of tumors lose the wild-type allele

neoplasm
increased rhabdomyosarcoma incidence ( J:237183 )
• mice develop multi-step embryonal rhabdomyosarcoma with a latency of 6 months
• majority of tumors lose the wild-type allele




Genotype
MGI:5882409
cx5
Allelic
Composition		 Tg(CKMM-tTA)A3Rhvh/0
Tg(tetO-Hgf,-EGFP)24Tcre/0
Genetic
Background		 involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CKMM-tTA)A3Rhvh mutation (2 available)
Tg(tetO-Hgf,-EGFP)24Tcre mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
abnormal skeletal muscle fiber morphology ( J:237183 )
• myofibers contain more myonuclei than controls
decreased skeletal muscle fiber size ( J:237183 )
• mice exhibit a modest reduction of muscle fiber size
• however, mice show normal postnatal muscle growth
increased satellite cell number ( J:237183 )
• mice exhibit a higher number of satellite cells compared to controls
• MyoD-positive cells are seen in muscle sections indicating presence of activated satellite cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/02/2024
MGI 6.13 		The Jackson Laboratory