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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mirc1tm2.1Aven
targeted mutation 2.1, Andrea Ventura
MGI:5648458
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mirc1tm2.1Aven/Mirc1tm2.1Aven B6.Cg-Mirc1tm2.1Aven MGI:5661549
hm2
 		Mirc1tm2.1Aven/Mirc1tm2.1Aven involves: 129S4/SvJae * C57BL/6 * SJL/J MGI:5661546
cx3
 		Mirc1tm2.1Aven/Mirc1tm2.1Aven
Tg(ARR2/Pbsn-MYC)7Key/0 		involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL/J MGI:5662416
cx4
 		Mirc1tm2.1Aven/Mirc1tm2.1Aven
Tg(IghMyc)22Bri/? 		involves: 129S4/SvJae * C57BL/6 * SJL/J MGI:5662410
cx5
 		Mirc1tm2.1Aven/Mirc1+
Tg(IghMyc)22Bri/? 		involves: 129S4/SvJae * C57BL/6 * SJL/J MGI:5662414


Genotype
MGI:5661549
hm1
Allelic
Composition		 Mirc1tm2.1Aven/Mirc1tm2.1Aven
Genetic
Background		 B6.Cg-Mirc1tm2.1Aven
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm2.1Aven mutation (1 available); any Mirc1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, incomplete penetrance ( J:223213 )
• heterozygote x heterozygote matings produce 5% homozygotes rather than the expected 25%

skeleton
vertebral fusion ( J:223213 )
• 20% of mice exhibit vertebral fusion




Genotype
MGI:5661546
hm2
Allelic
Composition		 Mirc1tm2.1Aven/Mirc1tm2.1Aven
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm2.1Aven mutation (1 available); any Mirc1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell number ( J:223213 )
• decrease in total splenic B cells
decreased myeloid cell number ( J:223213 )
• decrease in total splenic myeloid cell (CD11b+) number

immune system
decreased B cell number ( J:223213 )
• decrease in total splenic B cells




Genotype
MGI:5662416
cx3
Allelic
Composition		 Mirc1tm2.1Aven/Mirc1tm2.1Aven
Tg(ARR2/Pbsn-MYC)7Key/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm2.1Aven mutation (1 available); any Mirc1 mutation (6 available)
Tg(ARR2/Pbsn-MYC)7Key mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
small prostate gland ( J:223213 )
• prostate volume is reduced compared to Tg(ARR2/Pbsn-MYC)7Key alone
decreased prostate gland tumor incidence ( J:223213 )
• prostrates from 8 week old males exhibit occasional prostatic intraepithelial neoplasia in contrast to Tg(ARR2/Pbsn-MYC)7Key alone
increased prostate gland adenocarcinoma incidence ( J:223213 )
• invasive prostatic adenocarcinoma is not observed until 14 months of age in contrast to Tg(ARR2/Pbsn-MYC)7Key alone

reproductive system
small prostate gland ( J:223213 )
• prostate volume is reduced compared to Tg(ARR2/Pbsn-MYC)7Key alone
decreased prostate gland tumor incidence ( J:223213 )
• prostrates from 8 week old males exhibit occasional prostatic intraepithelial neoplasia in contrast to Tg(ARR2/Pbsn-MYC)7Key alone
increased prostate gland adenocarcinoma incidence ( J:223213 )
• invasive prostatic adenocarcinoma is not observed until 14 months of age in contrast to Tg(ARR2/Pbsn-MYC)7Key alone

neoplasm
decreased prostate gland tumor incidence ( J:223213 )
• prostrates from 8 week old males exhibit occasional prostatic intraepithelial neoplasia in contrast to Tg(ARR2/Pbsn-MYC)7Key alone
increased prostate gland adenocarcinoma incidence ( J:223213 )
• invasive prostatic adenocarcinoma is not observed until 14 months of age in contrast to Tg(ARR2/Pbsn-MYC)7Key alone




Genotype
MGI:5662410
cx4
Allelic
Composition		 Mirc1tm2.1Aven/Mirc1tm2.1Aven
Tg(IghMyc)22Bri/?
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm2.1Aven mutation (1 available); any Mirc1 mutation (6 available)
Tg(IghMyc)22Bri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased B cell apoptosis ( J:223213 )
• increase in pre-B cell apoptosis as compared to mice carrying Tg(IghMyc)22Bri alone

mortality/aging
abnormal survival ( J:223213 )
• increase in survival as compared to mice carrying Tg(IghMyc)22Bri alone and mice carrying Tg(IghMyc)22Bri and heterozygous for Mirc1tm2.1Aven

hematopoietic system
increased B cell apoptosis ( J:223213 )
• increase in pre-B cell apoptosis as compared to mice carrying Tg(IghMyc)22Bri alone
abnormal pre-B cell morphology ( J:223213 )
• bone marrow of 5 week old mice is not characterized by an accumulation of pre-B cells as compared to Tg(IghMyc)22Bri

immune system
increased B cell apoptosis ( J:223213 )
• increase in pre-B cell apoptosis as compared to mice carrying Tg(IghMyc)22Bri alone
abnormal pre-B cell morphology ( J:223213 )
• bone marrow of 5 week old mice is not characterized by an accumulation of pre-B cells as compared to Tg(IghMyc)22Bri

neoplasm
increased B cell derived lymphoma incidence ( J:223213 )
• immunophenotype of B cell lymphomas is altered (increase in in IgM+ tumors) as compared to Tg(IghMyc)22Bri alone
increased tumor latency ( J:223213 )
• as compared to mice carrying only Tg(IghMyc)22Bri




Genotype
MGI:5662414
cx5
Allelic
Composition		 Mirc1tm2.1Aven/Mirc1+
Tg(IghMyc)22Bri/?
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm2.1Aven mutation (1 available); any Mirc1 mutation (6 available)
Tg(IghMyc)22Bri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
abnormal survival ( J:223213 )
• increase in survival as compared to mice carrying Tg(IghMyc)22Br




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory