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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mirc1tm3.1Aven
targeted mutation 3.1, Andrea Ventura
MGI:5648471
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mirc1tm3.1Aven/Mirc1tm3.1Aven B6.Cg-Mirc1tm3.1Aven MGI:5662404
hm2
 		Mirc1tm3.1Aven/Mirc1tm3.1Aven involves: 129S4/SvJae * C57BL/6 * SJL/J MGI:5662406
ht3
 		Mirc1tm3.1Aven/Mirc1+ B6.Cg-Mirc1tm3.1Aven MGI:5662403
ht4
 		Mirc1tm3.1Aven/Mirc1+ involves: 129S4/SvJae * C57BL/6 * SJL/J MGI:5662405


Genotype
MGI:5662404
hm1
Allelic
Composition		 Mirc1tm3.1Aven/Mirc1tm3.1Aven
Genetic
Background		 B6.Cg-Mirc1tm3.1Aven
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm3.1Aven mutation (1 available); any Mirc1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo

limbs/digits/tail
fused carpal bones ( J:223213 )
• 21% of mice exhibit fusion of the proximal carpal bones
brachyphalangia ( J:223213 )
• the fifth mesophalanx of the forelimb is shortened as compared to controls and heterozygotes

mortality/aging
perinatal lethality, incomplete penetrance ( J:223213 )
• heterozygote x heterozygote matings produce 3% homozygotes rather than the expected 25%

skeleton
fused carpal bones ( J:223213 )
• 21% of mice exhibit fusion of the proximal carpal bones
brachyphalangia ( J:223213 )
• the fifth mesophalanx of the forelimb is shortened as compared to controls and heterozygotes
vertebral fusion ( J:223213 )
• 57% of mice exhibit vertebral fusion
thoracic vertebral transformation ( J:223213 )
• all mice exhibit transformation of vertebra 14 (T7 to T8)
• all mice exhibit transformation of vertebra 20 (T13 to L1a)
lumbar vertebral transformation ( J:223213 )
• all mice exhibit transformation of vertebra 26 (L6 to S1)




Genotype
MGI:5662406
hm2
Allelic
Composition		 Mirc1tm3.1Aven/Mirc1tm3.1Aven
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm3.1Aven mutation (1 available); any Mirc1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased B cell apoptosis ( J:223213 )
• increase in fraction of apoptotic pre-B cells

growth/size/body
decreased body weight ( J:223213 )
• 4-5 week old mice weigh 52% less than controls

hematopoietic system
increased B cell apoptosis ( J:223213 )
• increase in fraction of apoptotic pre-B cells
decreased B cell number ( J:223213 )
• decrease in total splenic B cells
• decrease in ratio of splenic B cells to T cells and myeloid cells
decreased pre-B cell number ( J:223213 )
• decrease in percentage of pre-B cells in bone marrow
• reduction in pre-B cell numbers
decreased alpha-beta T cell number ( J:223213 )
• decrease in total splenic T cells
decreased myeloid cell number ( J:223213 )
• decrease in total splenic myeloid cell (CD11b+) number
small spleen ( J:223213 )
• reduced spleen size as compared to controls

immune system
increased B cell apoptosis ( J:223213 )
• increase in fraction of apoptotic pre-B cells
decreased B cell number ( J:223213 )
• decrease in total splenic B cells
• decrease in ratio of splenic B cells to T cells and myeloid cells
decreased pre-B cell number ( J:223213 )
• decrease in percentage of pre-B cells in bone marrow
• reduction in pre-B cell numbers
decreased alpha-beta T cell number ( J:223213 )
• decrease in total splenic T cells
small spleen ( J:223213 )
• reduced spleen size as compared to controls




Genotype
MGI:5662403
ht3
Allelic
Composition		 Mirc1tm3.1Aven/Mirc1+
Genetic
Background		 B6.Cg-Mirc1tm3.1Aven
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm3.1Aven mutation (1 available); any Mirc1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
brachyphalangia ( J:223213 )
• the fifth mesophalanx of the forelimb is shortened, but the phenotype is less severe than in homozygotes

skeleton
brachyphalangia ( J:223213 )
• the fifth mesophalanx of the forelimb is shortened, but the phenotype is less severe than in homozygotes




Genotype
MGI:5662405
ht4
Allelic
Composition		 Mirc1tm3.1Aven/Mirc1+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm3.1Aven mutation (1 available); any Mirc1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:223213 )
• 4-5 week old mice weigh 16% less than controls, but more than homozygotes




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory