All Phenotypes Mirc1<tm4.1Aven> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mirc1^tm4.1Aven
targeted mutation 4.1, Andrea Ventura
MGI:5648475

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mirc1^tm4.1Aven/Mirc1^tm4.1Aven	B6.Cg-Mirc1^tm4.1Aven	MGI:5662399
hm2	Mirc1^tm4.1Aven/Mirc1^tm4.1Aven	involves: 129S4/SvJae * C57BL/6 * SJL/J	MGI:5662401
ht3	Mirc1^tm4.1Aven/Mirc1⁺	B6.Cg-Mirc1^tm4.1Aven	MGI:5662398
ht4	Mirc1^tm4.1Aven/Mirc1⁺	involves: 129S4/SvJae * C57BL/6 * SJL/J	MGI:5662400

Allelic Composition	Mirc1^tm4.1Aven/Mirc1^tm4.1Aven
Genetic Background	B6.Cg-Mirc1^tm4.1Aven

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1^tm4.1Aven mutation (1 available); any Mirc1 mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

cleft palate ( J:223213 )

digestive/alimentary system

cleft palate ( J:223213 )

growth/size/body

cleft palate ( J:223213 )

limbs/digits/tail

fused carpal bones ( J:223213 )

• all mice exhibit fusion of the proximal carpal bones

abnormal phalanx morphology ( J:223213 )

• the fifth mesophalanx of the forelimb is absent in E18.5 embryos

mortality/aging

perinatal lethality, complete penetrance ( J:223213 )

skeleton

fused carpal bones ( J:223213 )

• all mice exhibit fusion of the proximal carpal bones

abnormal phalanx morphology ( J:223213 )

• the fifth mesophalanx of the forelimb is absent in E18.5 embryos

thoracic vertebral transformation ( J:223213 )

• all mice exhibit transformation of vertebra 14 (T7 to T8)

• all mice exhibit transformation of vertebra 20 (T13 to L1a)

lumbar vertebral transformation ( J:223213 )

• all mice exhibit transformation of vertebra 26 (L6 to S1)

vertebral fusion ( J:223213 )

• all mice exhibit vertebral fusion

delayed bone ossification ( J:223213 )

Allelic Composition	Mirc1^tm4.1Aven/Mirc1^tm4.1Aven
Genetic Background	involves: 129S4/SvJae * C57BL/6 * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1^tm4.1Aven mutation (1 available); any Mirc1 mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:223213 )

respiratory system

pulmonary hypoplasia ( J:223213 )

Allelic Composition	Mirc1^tm4.1Aven/Mirc1⁺
Genetic Background	B6.Cg-Mirc1^tm4.1Aven

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1^tm4.1Aven mutation (1 available); any Mirc1 mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

brachyphalangia ( J:223213 )

• the fifth mesophalanx of the forelimb is shortened, but phenotype is less severe than in homozygotes

skeleton

brachyphalangia ( J:223213 )

• the fifth mesophalanx of the forelimb is shortened, but phenotype is less severe than in homozygotes

Allelic Composition	Mirc1^tm4.1Aven/Mirc1⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6 * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1^tm4.1Aven mutation (1 available); any Mirc1 mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:223213 )

• 4-5 week old mice weigh less than controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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