Phenotypes associated with this allele

• Allele Symbol: Sik1^tm1.1Berd
• Allele Name: targeted mutation 1.1, Rebecca Berdeaux
• Allele ID: MGI:5648546
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Sik1^tm1.1Berd/Sik1^tm1.1Berd	involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL	MGI:5805510
cn2	Myf5^tm3(cre)Sor/Myf5^+ Sik1^tm1.1Berd/Sik1^tm1.1Berd	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J * SJL	MGI:5805512
cn3	Sik1^tm1.1Berd/Sik1^tm1.1Berd Tg(Adipoq-cre)1Evdr/0	involves: 129S7/SvEvBrd * C57BL/6J * FVB/NJ * SJL	MGI:5805515

Genotype
MGI:5805510

cn1

• Allelic Composition: Sik1^tm1.1Berd/Sik1^tm1.1Berd
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:236223 )

• mild in mice infected with a liver-specific cre expressing adenovirus and less so than in mice with global knockout of the gene

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:236223 )

N • when fed chow, mice infected with a liver-specific cre expressing adenovirus exhibit normal blood glucose when fed ad libitum or under fasted conditions and normal glucose tolerance

N • when fed a high-fat diet, mice infected with a liver-specific cre expressing adenovirus exhibit normal glucose or insulin tolerance

Genotype
MGI:5805512

cn2

• Allelic Composition: Myf5^tm3(cre)Sor/Myf5⁺; Sik1^tm1.1Berd/Sik1^tm1.1Berd
• Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J * SJL

homeostasis/metabolism

abnormal glucose homeostasis ( J:236223 )

• mice fed a high fat diet exhibit elevated glucose disposal and skeletal muscle 2-deoxyglucose uptake rates compared with control mice

decreased circulating insulin level ( J:236223 )

• mice fed a high fat diet exhibit a slightly weaker insulin response to glucose compared with control mice

abnormal gluconeogenesis ( J:236223 )

• slightly reduced basal glucose production during hyperinsulinemic euglycemic clamps requiring more exogenous glucose to achieve and maintain euglycemia in mice fed a high-fat diet

improved glucose tolerance ( J:236223 )

• mice fed a high-fat diet exhibit improved glucose tolerance at late time points compared with control mice

increased insulin sensitivity ( J:236223 )

• in mice fed a high-fat diet

muscle

muscle phenotype ( J:236223 )

N • mice exhibit grossly normal muscle structure without evidence of degeneration

increased skeletal muscle cell glucose uptake ( J:236223 )

• mice fed a high fat diet exhibit elevated skeletal muscle 2-deoxyglucose uptake rates compared with control mice

cellular

increased skeletal muscle cell glucose uptake ( J:236223 )

• mice fed a high fat diet exhibit elevated skeletal muscle 2-deoxyglucose uptake rates compared with control mice

Genotype
MGI:5805515

cn3

• Allelic Composition: Sik1^tm1.1Berd/Sik1^tm1.1Berd; Tg(Adipoq-cre)1Evdr/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/NJ * SJL

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:236223 )

N • mice fed chow or a high-fat diet exhibit normal glucose homeostasis