Phenotypes associated with this allele

• Allele Symbol: Disc1^{tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho}
• Allele Name: targeted mutation 1, Xianjin Zhou
• Allele ID: MGI:5648808
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Disc1^tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho/Disc1^+	(129S2/SvPasCrl x C57BL)F1	MGI:5660926
ht2	Disc1^tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho/Disc1^del	129S2/SvPasCrl-Disc1^del Disc1^tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho	MGI:5660929

Genotype
MGI:5660926

ht1

• Allelic Composition: Disc1^{tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho}/Disc1⁺
• Genetic Background: (129S2/SvPasCrl x C57BL)F1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavioral response to xenobiotic ( J:214737 )

♂ • males show a larger increase in total distance traveled, counts, and transitions in locomotion after ketamine injection than sibling controls

decreased startle reflex ( J:214737 )

• mice show a large startle variation between individuals with a significant number of mice with low startle (<50)

• however, prepulse inhibition and habituation of acoustic startle are normal

Genotype
MGI:5660929

ht2

• Allelic Composition: Disc1^{tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho}/Disc1^del
• Genetic Background: 129S2/SvPasCrl-Disc1^del Disc1^{tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho}

growth/size/body

decreased body size ( J:214737 )

♂ • males, but nor females, are slightly, but significantly, smaller than control littermates

decreased body weight ( J:214737 )

♂ • males, but not females, show slightly, but significantly, reduced body weight at P103

behavior/neurological

abnormal behavioral response to xenobiotic ( J:214737 )

♂ • males show a larger increase in total distance traveled, counts, and transitions in locomotion after ketamine injection in all time blocks except for the first and last one than sibling controls, indicating increased and prolonged responses to ketamine

low sweet preference ( J:214737 )

♀ • females, but not males, show a lower preference for saccharin than control females

behavioral despair ( J:214737 )

• mice show more immobility time in the tail suspension test, indicating behavioral despair

increased startle reflex ( J:214737 )

• mice exhibit higher startle with less variation between individuals

hematopoietic system

anemia ( J:214737 )

♂ • incomplete penetrance, seen in 2 of 10 males

decreased hemoglobin content ( J:214737 )

♂ • 2 of 10 males show lower concentrations of hemoglobin, indicating different degrees of anemia

increased red blood cell distribution width ( J:214737 )

• increase in red blood cell distribution width

nervous system

nervous system phenotype ( J:214737 )

N • no gross anatomical abnormalities are seen in the brain

increased prepulse inhibition ( J:214737 )

• mice exhibit enhanced prepulse inhibition (PPI), or impaired prepulse facilitation, when PPI is conducted with a short ISI at 25 ms

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:214737